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TranscriptomicsLong Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analys...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-44240 | biostudies-arrayexpress
TranscriptomicsRegulation of the ESC transcriptome by nuclear long non-coding RNAs
We performed poly(A)+ RNA sequencing (Illumina GAIIx) from nuclear and whole cell RNA fractions of mouse AB2.2 embryonic stem cells (ESCs) and neural progenitors (NPCs) differentiated from ESCs. We further transfected AB2.2 ESCs with control antisense oligonucleotides (ASOs), or 2 independent ASOs e...
ORGANISM(S): Mus musculus 
2015-12-01 | E-MTAB-3198 | biostudies-arrayexpress
TranscriptomicsThe Nuclear-retained non-coding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell type-specific AS in a concentration and phosphorylation dependent manner. However, the mechanisms tha...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22963 | biostudies-arrayexpress
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