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UnknownLoss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.
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S-EPMC12714701 | biostudies-literature
ProteomicsNucleophagy removes cytotoxic trapped PARP1
Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination repair (HRR)-deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recent...
ORGANISM(S): Homo sapiens (Human) 
2026-04-15 | PXD071389 | Pride
Hdx-ms 
ProteomicsRole of Late Endosomal Autophagy-Dependent Secretion in Regulating ER and Mitochondrial Stress and Stress Communication
Late endosomal secretion is an unconventional mechanism that relies on VAMP7 and is upregulated in autophagy-null cells. Transcriptomic analysis of VAMP7 knockout (KO) cells revealed significant changes in the expression of genes related to the mitochondria and endoplasmic reticulum (ER) stress. We ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-26 | PXD057152 | Pride
Mitochondrail stress Autophagy Vamp7 
ProteomicsMetalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Removal
Cytotoxicity of DNA-protein crosslinks (DPCs) is ascribed largely to their ability to block the progression of DNA replication fork. DPCs are frequently occurring in cells, either as a consequence of metabolism or exogenous agents. The mechanism of DPCs removal is not completely understood. Here, we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080743 | MassIVE
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