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TranscriptomicsTranscription profiling of human NT2 cell line treated with DMSO vs. retinoic acid
NT2 cells were treated with DMSO (control) or 10uM Retinoic Acid (RA). Total RNA was isolated using TriReagent, and subsequent cleanup with RNeasy columns (Qiagen) according to the manufacturer's directions. Hybridizations were performed according to Affymetrix guidelines using the Human HG-U133A ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2448 | biostudies-arrayexpress
TranscriptomicsGene expression data from 62 colorectal cancers
We stratified colorectal tumor samples using a new unsupervised, iterative method based on non-negative matrix factorization (NMF). The resulting five subtypes exhibited activation of specific signaling pathways, and significant differences in microsatellite status and tumor location. We could also ...
ORGANISM(S): Homo sapiens 
2013-01-14 | E-GEOD-35896 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling using total RNA [BMM, MPI and SPG]
Differentiation of myeloid progenitor cells leads to distinct populations of mononuclear phagocytes.Various macrophages exhibit distinct biological properties. Here wanted to delineate and characterize gene expression patterns in bone marrow derived macrophages Here wanted to delineate and characte...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-47473 | biostudies-arrayexpress
Transcriptomicsbulk RNA-seq NOHA
Bulk RNA sequencing (bulk RNA-seq) data of the Neural Organoid Hormonal Atlas (NOHA). To investigate the impact of hormonal modulation on neurodevelopmental processes, we used neural organoids derived from two genetically validated human induced pluripotent stem cell (hiPSC) control lines (CTL08, ma...
ORGANISM(S): Homo sapiens 
2026-07-22 | E-MTAB-17185 | biostudies-arrayexpress
TranscriptomicsscRNAseq NOHA
To investigate the impact of hormonal modulation on neurodevelopmental processes, we performed single-cell RNA sequencing (ScRNA-seq) on neural organoids derived from two genetically validated human induced pluripotent stem cell (hiPSC) control lines (CTL08, male; CTL04, female). Organoids were chro...
ORGANISM(S): Homo sapiens 
2026-07-22 | E-MTAB-17184 | biostudies-arrayexpress
TranscriptomicsMolecular Signatures of Fetal and Adult Prostate Stem Cells
The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. A distinctive core of transcriptional regulators common to both fetal and adult primit...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-15580 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes
Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress
UnknownSARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination.
Not available
S-EPMC9762734 | biostudies-literature
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