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TranscriptomicsA comparison of mono-culture and co-culture model containing fibroblasts
Organotypic three dimensional cultures of epithelial cells are grown at the air–liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of in vivo cellular responses could be better manifested in co-culture models in which additional cell-types such as fibroblasts were ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-MTAB-3462 | biostudies-arrayexpress
TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN BRONCHIAL TISSUE CULTURES
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5179 | biostudies-arrayexpress
TranscriptomicsSystems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
The development of reduced-risk products is aimed at providing adult smokers, who are unable to quit, with alternatives to cigarettes that present less risk of harm and smoking-related disease. The use of flavors in the development of these reduced-risk products fulfils an important role in product ...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7748 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (small airway epithelial cells-mRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6610 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (small airway epithelial cells-microRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6611 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (nasal epithelial cells-microRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6609 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (nasal epithelial cells-mRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6608 | biostudies-arrayexpress
TranscriptomicsA lower impact of exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke (CS) exposure. We conducted a series of in vitro studies to compare the biological impact of an acute exposure to aeroso...
ORGANISM(S): Homo sapiens 
2019-03-25 | E-MTAB-7577 | biostudies-arrayexpress
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsSystems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures (miRNA dataset).
Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including periodontal diseases, gingivitis, and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing the risk o...
ORGANISM(S): Homo sapiens 
2018-03-01 | E-MTAB-6545 | biostudies-arrayexpress
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