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GenomicNEIGHBOR Consortium Glaucoma GWAS

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238 | dbGaP
TranscriptomicsTranscription profiling of mouse Sod2-/- and Sod2+/+ erythroblasts.
The mitochondrial superoxide dismutase (SOD2) is a major antioxidant protein which detoxifies superoxide anion radicals generated by mitochondrial respiration (Weisiger and Fridovich, J. Biol. Chem. 1973). We designed a model of oxidative stress-induced anemia caused by SOD2-deficiency (Friedman et...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-8726 | biostudies-arrayexpress
GenomicGlaucoma Exome Sequencing

This is a study of primary open angle glaucoma (POAG) conducted through exome sequencing of cases and comparison of variant frequencies with general population frequencies available in dbGAP and controlled for sequencing platform artifact to minimize false positives.

POAG is an intraocular...

phs000558 | dbGaP
TranscriptomicsGrhl2 regulated genes in the mouse lung epithelial MLE15 cell line
The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for ...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40729 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia samples to improve prognosis and predict therapeutic response
Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy, characterized by a variable clinical course. While clinical and laboratory parameters are increasingly being used to refine prognosis, they do not accurately predict response to commonly used therapy. We used gene expression profilin...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-10137 | biostudies-arrayexpress
UnknownCirculating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection.
Not available
S-EPMC6938980 | biostudies-literature
UnknownInhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy.
Not available
S-EPMC7005627 | biostudies-literature
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
UnknownReproducibility of spatial penalty-based methodologies for intravoxel incoherent motion analysis with diffusion MRI.
Not available
S-EPMC11445472 | biostudies-literature
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
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