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TranscriptomicsTranscription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS
MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12764 | biostudies-arrayexpress
UnknownGenome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.

Background and aims

Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep inte...
S-EPMC12757440 | biostudies-literature
UnknownMutual learning for joint disease detection and severity prediction reveals multimodal pathogenesis for neurodegenerative disorders.

Motivation

Neurodegenerative disorders influence millions of people worldwide, and uncovering the pathogenesis is of urgent need. Many efforts have been made to detect or predict neurodegenerative disorders, while exploring the pathogenesis has been ignored from a systemic perspective.

Re...

S-EPMC12758602 | biostudies-literature
UnknownTowards cascading genetic risk in Alzheimer's disease.
Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be either positive...
S-EPMC11292901 | biostudies-literature
UnknownNeuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.

Background and objectives

Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins ...
S-EPMC12015082 | biostudies-literature
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH to these deficits rem...
S-EPMC11629703 | biostudies-literature
UnknownMapping genomic loci implicates genes and synaptic biology in schizophrenia.
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genom...
S-EPMC9392466 | biostudies-literature
UnknownDeep learning enhanced ALPS reveals genetic and environmental factors of brain glymphatic function.

Background

The glymphatic system plays a critical role in brain waste clearance and health. Diffusion tensor imaging along the perivascular space (DTI-ALPS) is an emerging approach to assess glymphatic function, but manual analysis is limited by its subjectivity and laboriousness in clinical...
S-EPMC12878677 | biostudies-literature
UnknownVitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction.

Purpose

To evaluate vitrectomy for diabetic macular edema (DME) in eyes with at least moderate vision loss and vitreomacular traction.

Design

Prospective cohort study.

Participants

The primary cohort included 87 eyes with DME and vitreomacular traction based on investigator's e...
S-EPMC2911350 | biostudies-literature
UnknownExtracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors.
The Extracorporeal Life Support Organization (ELSO) maintains the world's largest extracorporeal membrane oxygenation (ECMO) registry by volume, center participation, and international scope. This 2022 ELSO Registry Report describes the program characteristics of ECMO centers, processes of ECMO care...
S-EPMC10962646 | biostudies-literature
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