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TranscriptomicsHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression Gene expression of the following mouse livers were characterized A. WT (n=3). B. Pten-/- (n...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-66717 | biostudies-arrayexpress
GenomicNEIGHBOR Consortium Glaucoma GWAS

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238 | dbGaP
TranscriptomicsGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
The effect of Tlr4P712H mutation (rendering TLR4 non-functional), or gut-sterilization by antbiotics, on the induction of tumorgenesis by CCl4 and diethylnitrosamine (DEN) was characterized. Affymetrix Mouse 430 2.0 gene expression measurements were used to characterize the transcriptomic basis of t...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-33446 | biostudies-arrayexpress
TranscriptomicsAger (Rage) and Myd88 deletion in resected mouse livers
The effect of resection of mouse livers on survival serve as a model for the effect of resection of human livers, which are performed for both the purposes of removing sick tissue and for transplanting healthy tissue. When less than 70% of a mouse liver is resected, the mouse usually lives. However,...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-22873 | biostudies-arrayexpress
UnknownBioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling.
Not available
S-EPMC8409064 | biostudies-literature
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
TranscriptomicsDeactivation of Hepatic Stellate Cells during Liver Fibrosis Resolution in Mice
Gene expression of mouse hepatic stellate cells was characterized under the following conditions: Quiescent (isolated from normal mouse liver) and reverted (isolated from mouse liver treated with 4 injections of carbontetrachloride followed by 45 day rest period) Affymetrix Mouse 1.0ST gene express...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-38648 | biostudies-arrayexpress
TranscriptomicsGene Expression of ApoE Null and ApoE Null/RAGE Diabetic and Non-diabetic Mice
The multi-ligand Receptor for AGE (RAGE) contributes to atherosclerosis in apolipoprotein (ApoE) null mice in both the non-diabetic and diabetic states. Previous studies using soluble RAGE, the extracellular ligand-binding domain of RAGE, or homozygous RAGE null mice showed that blockade or deletion...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-15729 | biostudies-arrayexpress
TranscriptomicsGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
The effect of Tlr4P712H mutation (rendering TLR4 non-functional), or gut-sterilization by antibiotics, on the induction of tumorgenesis by CCl4 and diethylnitrosamine (DEN) was characterized. Affymetrix Mouse 430 2.0 gene expression measurements were used to characterize the transcriptomic basis of ...
ORGANISM(S): Mus musculus 
2014-07-04 | E-GEOD-30485 | biostudies-arrayexpress
TranscriptomicsEffect of transgenic human IL8 on gene expression in mouse colon cancer tumors
mRNA expression in colon cancer tumores of CBA/C57BL/6 transgenic mice bearing a BAC which contains the human IL8 gene and promoter was compared to that of CBA/C57BL/6 controls. A. CBA/C57BL/6 mice controls (n=3) B. human IL8 transgenic CBA/C57BL/6 mice (n=3).
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-39273 | biostudies-arrayexpress
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