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TranscriptomicsTranscription profiling of human lymphoblastoid cell lines that are part of the NIHPDR exposed to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) to identify novel predictors of resistance to DNA damaging agents
We have investigated whether gene expression signatures can be used to predict inter-individual responses to DNA damaging agents; We used microarrays to detail inter-individual variation in gene expression across a healthy population under basal and damage induced conditions Experiment Overall Desig...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-10313 | biostudies-arrayexpress
ProteomicsPrenatal Exposure to Metals Alters the Placental Inflammatory Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns
Prenatal exposure to toxic metals is associated with altered placental function and adverse health outcomes. The underlying mechanisms linking in utero toxic metal exposures with later-in-life health remain unclear, though placental inflammation is posited as a potential driver. The aim of this stud...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041694 | Pride
Human Placenta Metal exposure Biomarker 
TranscriptomicsFormaldehyde-induced changes in microRNA signaling
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42395 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48355 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome: altered gene expression profiles in newborn cord blood
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established to better understand the impacts of prenatal exposure to inorganic arsenic (iAs). In this study, we examined a subset (n = 40) of newborn cord blood samples for microRNA (miRNA) expression...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48354 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome: altered miRNA expression profiles in newborn cord blood
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established to better understand the impacts of prenatal exposure to inorganic arsenic (iAs). In this study, we examined a subset (n = 40) of newborn cord blood samples for microRNA (miRNA) expression...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48353 | biostudies-arrayexpress
TranscriptomicsOzone Exposure Alters MicroRNA Expression Profiles in Humans
We set out to test the hypothesis that ozone inhalation exposure significantly alters miRNA expression profiles within the airway of humans. Adult human volunteers were exposed to 0.4 ppm ozone for two hours. Induced sputum samples were collected from each subject 48 hours pre-exposure and 6 hours p...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-47977 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
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