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ProteomicsProteome profiling of MOLM-13 cells treated with proposed CK1α degraders
Targeted Protein Degradation (TPD) encompasses two approaches that generate small molecules with similar proteasome-dependent mechanisms of action: Proteolysis-Targeting Chimeras (PROTACs) and Molecular Glues (MGs). Our goal is to develop novel MG approaches that exploit the E3 ubiquitin ligase Cere...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045228 | Pride
Acute leukemia Targeted protein degradation Tmt Molecular glues Lc-ms/ms 
ProteomicsTMT analysis of MOLM-13 cells treated with SJ001007095
Targeted Protein Degradation (TPD) encompasses two approaches that generate small molecules with similar proteasome-dependent mechanisms of action: Proteolysis-Targeting Chimeras (PROTACs) and Molecular Glues (MGs). Our goal is to develop novel MG approaches that exploit the E3 ubiquitin ligase Cere...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045170 | Pride
Acute leukemia Targeted protein degradation Tmt Molecular glues Lc-ms/ms 
ProteomicsTMT analysis of MOLM-13 cells treated with series 3 CK1a degraders
Targeted Protein Degradation (TPD) encompasses two approaches that generate small molecules with similar proteasome-dependent mechanisms of action: Proteolysis-Targeting Chimeras (PROTACs) and Molecular Glues (MGs). Our goal is to develop novel MG approaches that exploit the E3 ubiquitin ligase Cere...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045230 | Pride
Acute leukemia Targeted protein degradation Tmt Molecular glues Lc-ms/ms 
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