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ProteomicsA novel mobile genomic island: introducing ‘cephalosporinase morons’ in Enterobacteriaceae
The exchange of mobile genomic islands (MGIs) between microorganisms is often mediated by phages. As a consequence, not only phage genes are transferred, but also genes that have no particular function in the phage's lysogenic cycle. If they provide benefits to the phage's host, such genes are refer...
ORGANISM(S): Enterobacter cloacae 
2018-08-21 | PXD007113 | Pride
"cephalosporin resistance " Enterobacteriaceae "mobile genomic islands " 
ProteomicsN-terminomics for the identification of in-vitro substrates and cleavage site specificity of the SARS-CoV-2 main protease
The genome of coronaviruses, including the SARS-CoV-2, which causes the human pandemic COVID-19, encodes for two proteases, a papain like (PL) and the so-called Main protease (Mpro), also named 3CLpro or non-structural protein 5 (NSP5). Mpro is activated by autoproteolysis, and true to its name, is ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-02 | PXD021406 | Pride
Sars-cov-2 Sars-cov N-terminomics Lcms Proteomics 
ProteomicsAnalysis of the cellular effect of 1α,25-dihydroxyvitamin D3 on lung NCI-H441 cells
Low serum levels or deficiency of 1α,25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or acute respiratory distress syndrome, although the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, a...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040622 | Pride
Vitamin d3 Nci-h441 cells Alveolar-capillary barrier Lung Isobaric labelling Biomarker 
TranscriptomicsImmunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation
To investigate factors that might influence the T-cell suppressive capabilities of mesenchymal stroma cells, T-cell suppressive and non-suppressive mesenchymal stroma cells were compared. Immunosuppressive capabilities of MSCs was determined via T-cell proliferation assay.
ORGANISM(S): Homo sapiens 
2015-01-20 | E-MTAB-2396 | biostudies-arrayexpress
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
TranscriptomicsRNA-Seq of the rectus femoris muscle of mice after 3-week treadmill training versus sedentary control
This study investigates the effects of exercise and genetic predisposition on the transcriptomic profile of the rectus femoris muscle of long-term selected marathon (DUhTP) and non-inbred (DUC) mice. All mice used in this experiment were male. In the exercise group, mice underwent treadmill training...
ORGANISM(S): Mus musculus 
2024-11-24 | E-MTAB-12072 | biostudies-arrayexpress
ProteomicsThe hematopoietic master transcription factor PU.1 requires its interaction with the SWI/SNF remodeler to access chromatin de novo
PU.1 is a prototype master transcription factor (TF) of hematopoietic cell differentiation with diverse roles in different lineages. Analysis of its genome-wide binding pattern across PU.1 expressing cell types revealed manifold cell type-specific binding patterns. They are not consistent with the e...
ORGANISM(S): Homo sapiens (Human) 
2019-11-20 | PXD013167 | Pride
Chromatin remodelling Transcription factor Cell differenciation 
TranscriptomicsBezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), is generally used to treat hyperlipidemia. Clinical trials on patients suffering from type 2 diabetes indicated that BEZ also has beneficial effects on glucose metabolism, but the underlying mechanisms remain ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-79008 | biostudies-arrayexpress
UnknownZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer
Not available
S-SCDT-10_1038-S44319-024-00186-7 | biostudies-other
UnknownNRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo
Not available
S-SCDT-10_1038-S44318-025-00520-2 | biostudies-other
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