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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
ProteomicsMechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota
Marine brown algae produce the highly recalcitrant polysaccharide fucoidan, contributing to long-term oceanic carbon storage and climate regulation. Fucoidan is degraded by specialized heterotrophic bacteria, which promote ecosystem function and global carbon turnover using largely uncharacterized m...
ORGANISM(S): Planctomycetales 
2024-11-22 | PXD057797 | Pride
Fucoidan breakdown Carbon sequestration Macroalgal-associated bacteria Endo-fucanase gh168 Planctomycetota 
GenomicsFucoidan project
Effect of fucoidan on gut microbiome
PRJEB94966 | ENA
ProteomicsDecreased Expression of Immune Activator WARS1 and Other Pro-inflammatory Mediators in Type 1-like Macrophages as an associated Mechanism in Response to Fucoidan from Marine Brown Algae
Background/Aim: Macrophages are key regulators of innate and adaptive immune responses through antigen presentation and the production of inflammatory mediators and growth factors. Imbalances in the activation and inhibition of pro-inflammatory type 1-like macrophages (M1) and anti-inflammatory type...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD082514 | Pride
Fucoidan Wars1 Inflammation Saccharine latissima Macrophages Proteomics 
TranscriptomicsFucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse reaction of chemotherapy with limited treatment. Previous research indicates neutrophil extracellular traps (NETs) is a critical pathogenesis of CIPN. LPS/HMGB1 serve as important inducers of NETs. Here, we aim to target inhibiti...
ORGANISM(S): Mus musculus 
2025-04-09 | GSE249275 | GEO
GenomicsFucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
Fucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
PRJNA1048422 | ENA
UnknownCharacterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll of Undaria pinnatifida in Cyclophosphamide-Induced Immunosuppressed Mice.
Not available
S-EPMC6723532 | biostudies-literature
TranscriptomicsTranscriptomic analysis of PM2.5 and/or fucoidan-treated ARPE-19 retinal pigment epithelial cells
This study investigated the transcriptomic effects of PM2.5 in human ARPE-19 retinal pigment epithelial cells and evaluated the transcriptional responses associated with fucoidan treatment. ARPE-19 cells were assigned to four conditions: vehicle control, fucoidan (400 μg/mL), PM2.5 (200 μg/mL), and ...
ORGANISM(S): Homo sapiens 
2026-07-21 | GSE339345 | GEO
GenomicsTranscriptomic analysis of PM2.5 and/or fucoidan-treated ARPE-19 retinal pigment epithelial cells
Transcriptomic analysis of PM2.5 and/or fucoidan-treated ARPE-19 retinal pigment epithelial cells
PRJNA1498479 | ENA
TranscriptomicsAnti-proliferation activity of fucoidan on MKN45 gastric cancer cells and downregulation of phosphorylated ASK1, a cell-cycle-regulated cyclin-dependent kinase
Fucoidan is a high-molecular polysaccharide whose main constituent is sulfated fucose. Extensive studies have demonstrated numerous interesting biological activities for fucoidan. We specifically focused on the anti-proliferation activity of fucoidan and examined the underlying mechanism in MKN45 ga...
ORGANISM(S): Homo sapiens 
2017-02-09 | GSE58774 | GEO
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