INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...
Untargeted metabolomics is a popular method by which researchers measure a large portion of the metabolites present in a biological system at once. This approach usually results in complex data sets containing tens to hundreds of thousands of observations whi...
By using metabolomics technology, the molecular changes of seminal plasma over time under 4°C liquid preservation conditions were analyzed, and candidate biomarkers related to the functional decline of semen were screened out.
Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...
Abstract Objective: Functional constipation (FC) is a common gastrointestinal disorder that significantly affects quality of life. Increasing evidence suggests that gut microbiota and their derived metabolites play a critical role in FC, yet the therapeutic potential of Spirulina and its underlying ...
Background: Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes, yet microbiome-associated fun...
Widely targeted metabolomics based on UPLC-MS/MS was performed to explore metabolic differences between two tissues of Wolfiporia cocos sclerotium. Samples include inner white tissue (Fuling Bai) and outer layer (Fuling Pi) of sclerotium, with 3 biological replicates for each group. A total of 1565 ...
This study systematically elucidates the hierarchical signaling regulatory network in aerobic granular sludge (AGS) by integrating dynamic analysis of quorum sensing signal molecules, microbial community structure profiling, and metabolomic characterization. The research reveals that c-di-GMP fun...
Objective: The gut microbiota plays a crucial role in rectal adenocarcinoma (READ). Nonetheless, little is known about corresponding changes in gut microbiota–host interactions. This study aimed to identify the structure of the gut microbiota and the characteristics of faecal metabolites in patie...
The exceptional adaptability of insects to diverse food sources is central to their survival and evolutionary success. However, the molecular mechanisms underlying this rapid adaptation remain largely uncharacterized. In this study, adaptive phenotypic, transcriptomic, and metabolomic differences...
