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GenomicsGenome-wide binding profiles of an artificial zinc finger protein with or without a KLF3 functional domain
Transcription factors are often regarded as having two distinct components: a DNA binding domain (DBD) to allow binding to the regulatory region of a target gene and a trans-acting functional domain (FD) to modulate gene expression. Recently, it is becoming clear that the DBDs of transcription facto...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-69739 | biostudies-arrayexpress
TranscriptomicsKrüppel-like factor 3 KO and rescue expression data in murine embyronic fibroblasts
Krüppel-like factor 3 (KLF3) is a transcriptional repressor that has roles in adipogenesis, B-cell maturation and erythropoiesis (for review see Pearson et al., 2012). We profiled gene expression in murine embryonic fibroblasts (MEFs) where Klf3 had been knocked-out and where the same cell had been ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-44744 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of wildtype, Klf3 H275R homozygous and heterozygous, Klf3 CH gene trap homozygous and heterozygous E12.5 embryos
The aim of this experiment was to investigate the dysregulation of gene expression in whole E12.5 embryos containing a gene trap (CH) or point mutation (H275R) within the Klf3 gene Affymetrix microarrays were performed on RNA from wildtype, Klf3 H275R/H275R, Klf3 H275R/+, Klf3 CH homozygous and Klf3...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43908 | biostudies-arrayexpress
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