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TranscriptomicsTranscription profiling of human umbilical vein endothelial cells treated with Interferon-gamma (IFN-g), Borrelia burgdorferi or both IFN-g and Borrelia or untreated to investigate immune responses to Lyme disease
Borrelia burgdorferi, the agent of Lyme disease, promotes pro-inflammatory changes in endothelium that lead to the recruitment of leukocytes. The host immune response to infection results in increased levels of IFN-gamma in the serum and lesions of Lyme disease patients that correlate with greater s...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6092 | biostudies-arrayexpress
UnknownDiversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion.
Not available
S-EPMC1430824 | biostudies-literature
UnknownA phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus.
Not available
S-EPMC5007058 | biostudies-literature
UnknownB cells from African American lupus patients exhibit an activated phenotype.
Not available
S-EPMC5033941 | biostudies-literature
UnknownBelimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients.
Not available
S-EPMC6171800 | biostudies-literature
UnknownImmunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.
Not available
S-EPMC2195868 | biostudies-literature
UnknownB-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial.
Not available
S-EPMC8762029 | biostudies-literature
UnknownQuercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain.
Not available
S-EPMC4583019 | biostudies-literature
UnknownNovel evidence-based systemic lupus erythematosus responder index.
Not available
S-EPMC2748175 | biostudies-literature
TranscriptomicsGene Expression of F. tularensis LVS in hepatocytic cell line FL83B vs LVS cultured in MH broth
Transcriptional profiling of LVS grown in hepatocytic cell line FL83B was compared to that of LVS cultued in MH broth to discover genes important for intracellular growth. Two-condition experiment, Intracellular vs. Broth. Biological replicates: 4 Broth, 4 intracellular, independently grown and har...
ORGANISM(S): Francisella tularensis subsp. holarctica LVS 
2013-01-25 | E-GEOD-43731 | biostudies-arrayexpress
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