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TranscriptomicsFurin deficiency efect on T cells
Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells. CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP...
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-67884 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse naive T cells from T-cell specific furin knockouts and wild type littermates
Purified naive (CD4+ CD62L+ CD44-) T cells from 10-11 weeks old T cell specific Furin knockout (CD4-cre fur flox/flox) and littermate wild type (fur flox/flox) control mice were profiled for gene expression using Affymetrix MOE 430 2.0 microarray platform.
ORGANISM(S): Mus musculus 
2008-06-27 | E-MEXP-1682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse naive T cells isolated from CD4+ CD62L+ CD44- T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice reveals T cell-expressed proprotein convertase furin is essential for maintenance of peripheral tolerance
Furin is a proprotein convertase induced in activated T cells, reported to processes the anti-inflammatory cytokine TGFb-1. Herein, we show that conditional deletion of furin in T cells allowed for normal T cell development but impaired the function of regulatory T cells and effector cells, which p...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11884 | biostudies-arrayexpress
GenomicsSingle-cell RNA-seq analysis of WT and Furin KO TECs
Single-cell RNA-seq analysis of WT and Furin KO TECs
PRJNA796291 | ENA
ProteomicsSupplementary Dataset 24 - Furin PICS2 with N-terminally 2PCA-modified human proteome-derived peptide libraries
Furin PICS2 with N-terminally 2PCA-modified human proteome-derived peptide libraries
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-11 | MSV000091270 | MassIVE
TranscriptomicsFurin deficiency effect on T cells
Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells.
ORGANISM(S): Mus musculus 
2015-08-05 | GSE67884 | GEO
GenomicsDifferential Gene expression of furin knockout (KO) DLD1, HCA7 and HT29 colorectal cancer cells
Differential Gene expression of furin knockout (KO) DLD1, HCA7 and HT29 colorectal cancer cells
PRJNA542145 | ENA
GenomicsGenomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses
Furin cleavage in European SARS-related bat coronaviruses
PRJEB51900 | ENA
GenomicsRNA sequencing of U937 cell clones carrying 0,1 or 2 copies of FURIN gene
RNA sequencing of U937 cell clones carrying 0,1 or 2 copies of FURIN gene
PRJNA1044087 | ENA
TranscriptomicsMyeloid Cell Expressed Proprotein Convertase FURIN Attenuates Inflammation
The proprotein convertase enzyme FURIN processes immature pro-proteins into functional end- products. FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance. FURIN also promotes the infectivity of pathogens by activating bacteria...
ORGANISM(S): Mus musculus 
2016-12-30 | GSE84117 | GEO
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