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TranscriptomicsRNA-Sequencing of human papillary thyroid carcinomas
RNA-Sequencing analysis of 18 papillary thyroid carcinoma biopsies and of 4 healthy donors' thyroids. In this analysis we assessed differential gene expression and investigated the mutational landscape in this tumor type. Analysis of gene fusion was also performed, leading to the identification of a...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-64912 | biostudies-arrayexpress
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
ProteomicsEpiproteomic Profiling Identifies Histone H4 Hyperacetylation as a Prognostic Marker in Pleural Mesothelioma
Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as a consequence of asbestos exposure. Despite recent therapeutic advances, including immune checkpoint inhibitors and multimodal treatment strategies, the prognosis of PM remains poor, with a median overall survival...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD076262 | Pride
Histone post-translational modifications Pleural mesothelioma 
ProteomicsHistone PTM profiling in breast cancer clinical samples
Although cancer was long considered a genetic disease, the contribution of epigenetics to various aspects of cancer biology is now being increasingly recognized. In particular, aberrations in the deposition and maintenance of histone post-translational modifications (PTMs) can result in the inapprop...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD057150 | Pride
Breast cancer Histone post-translational modifications Epigenetics 
ProteomicsHistone PTM analysis in breast cancer cells treated with methyltransferase inhibitors
Histone PTM analysis were analyzed in breast cancer cells treated with methyltransferase inhibitors.
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD064421 | Pride
Histone post-translationa modifications Methyltransferase inhibitors 
ProteomicsTherapy-Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukaemia Blasts through loss of PRC2-Mediated Gene Regulation
We employed mass spectrometry to perform an unbiased, quantitative analysis of histone modifications in newly diagnosed AML patients stratified by senescence competency
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD065846 | Pride
Histone post-translationa modifications Acute myeloid leukaemia 
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