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TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq reveals activation of unique gene groups as a consequence of stem cell-parenchymal cell fusion
Fusion of donor mesenchymal stem cells with parenchymal cells of the recipient can occur in the brain, liver, intestine and heart following transplantation. The therapeutic benefit or detriment of resultant hybrids is unknown. Here we sought a global view of phenotypic diversification of mesenchym...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69926 | biostudies-arrayexpress
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
TranscriptomicsA new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
The identification of subtype-specific translocations has revolutionized diagnostics of sarcoma and provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-34800 | biostudies-arrayexpress
TranscriptomicsRadical prostatectomy specimens with and without TMPRSS2:ERG fusion from 139 patients with prostate in a Toronto cohort
Prostate tumors with the gene fusion TMPRSS2:ERG have been reported to have a significantly higher risk of recurrence compared with tumors lacking the fusion. Tumors from 139 patients who underwent radical prostatectomy were analyzed for the expression of 502 cancer-related genes to identify genes d...
ORGANISM(S): Homo sapiens 
2009-10-22 | E-GEOD-18655 | biostudies-arrayexpress
GenomicThe Finland-United States Investigation of NIDDM Genetics (FUSION) Study

The Finland-United States Investigation of NIDDM Genetics (FUSION) study is a long-term effort to identify genetic variants that predispose to type 2 diabetes (T2D) or that impact the variability of T2D-related quantitative traits. The initial effort involved linkage analysis of affected-sibling-...

phs000867 | dbGaP
TranscriptomicsLarge scale screening for known fusion genes in cancer cell lines
We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual stud...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-24737 | biostudies-arrayexpress
TranscriptomicsNUP98RARG gene fusion
A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia
ORGANISM(S): Homo sapiens 
2010-10-18 | E-MEXP-2928 | biostudies-arrayexpress
TranscriptomicsCell fusion-mediated pluripotent reprogramming triggers ordered changes in chromatin and gene expression across the human inactive X chromosome
Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic reprogramming in mouse, but human studies are hampered by Xi epigenetic instability and difficulties in tracking partially reprogra...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-77443 | biostudies-arrayexpress
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