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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
TranscriptomicsSingle-cell RNA-seq reveals activation of unique gene groups as a consequence of stem cell-parenchymal cell fusion
Fusion of donor mesenchymal stem cells with parenchymal cells of the recipient can occur in the brain, liver, intestine and heart following transplantation. The therapeutic benefit or detriment of resultant hybrids is unknown. Here we sought a global view of phenotypic diversification of mesenchym...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69926 | biostudies-arrayexpress
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
GenomicsGenome binding profile of the conserved CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells
The CSB-PGBD3 fusion protein arose over 43 million years ago when a 2.5 kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates. The CSB-PGBD3 fusion protein binds internally-deleted PGBD3 elements called MER85...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-37919 | biostudies-arrayexpress
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of CSB and the CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells
Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR). Over 43 Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable element integrated into intron 5 of the CSB...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56049 | biostudies-arrayexpress
GenomicsFunctional difference between TIF fusion protein and single protein
Functional difference between TIF fusion protein and single protein
PRJNA1055447 | ENA
TranscriptomicsTranscriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases
This SuperSeries is composed of the following subset Series: GSE35201: Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases [2007] GSE35202: Transcriptome ...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35203 | biostudies-arrayexpress
GenomicsEpigenetic regulation of FLT3 by ZNF384-fusion protein
Epigenetic regulation of FLT3 by ZNF384-fusion protein
PRJNA812608 | ENA
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