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ProteomicsNUP98-HOXA9 acute myeloid leukemia
Mass Spectrometry analysis of the interactome of the oncoprotein NUP98-HOXA9
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD001828 | Pride
Fusion protein nup98-hoxa9 Protein-protein interactions Aml 
UnknownDisclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach.
Not available
S-EPMC7407662 | biostudies-literature
TranscriptomicsDevelopment of NUP98-HOXA9 gene expression signatures
To explore the molecular mechanisms induced by the leukemic fusion protein NUP98-HOXA9, we performed gene expression analysis of human hematopoietic progenitors and primary samples of patients that express NUP98-HOXA9. By combining these data with ChIP-seq results, we observed that the fusion protei...
ORGANISM(S): Homo sapiens 
2016-12-31 | GSE62585 | GEO
TranscriptomicsMLL is essential for NUP98-HOXA9-induced leukemia
Rearrangements involving the NUP98 gene resulting in fusions to several partner genes occur in acute myeloid leukemia and myelodysplastic syndromes. This study demonstrates that the second FG repeat domain of the NUP98 moiety of the NUP98-HOXA9 fusion protein is important for its cell immortalizatio...
ORGANISM(S): Mus musculus 
2017-02-28 | GSE93923 | GEO
GenomicsEvaluation of the NUP98-HOXA9 role as oncogenic transcription factor
To study the oncogenic mechanism triggered by the leukemic fusion protein NUP98-HOXA9, we cloned the cDNA of NUP98-HOXA9 into a retroviral vector (pMSCV-IRES-GFP) and efficiently transduced the HEK293FT human cell line. We performed a ChIP-seq analysis to identify the DNA binding sites of NUP98-HOXA...
ORGANISM(S): Homo sapiens 
2016-12-31 | GSE62586 | GEO
TranscriptomicsTranscription profiling of mouse bone marrow cells expressing NUP98/HHEX or NUP98/HOXA9 a new oncogenic fusion with acute myeloid leukemia
We have cloned and characterized a fusion gene NUP98/HHEX1 resulting from t(7;10) from a patient with acute myeloid leukemia (AML). As NUP98/HHEX acts as an aberrant transcriptional activator, putative targets were searched upon transient expression of the fusion in primary murine bone marrow cells....
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10909 | biostudies-arrayexpress
UnknownAmino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
Not available
S-EPMC3234724 | biostudies-literature
UnknownA murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.
Not available
S-EPMC124303 | biostudies-literature
GenomicsMus musculus
MLL is essential for NUP98-HOXA9-induced leukemia
PRJNA362844 | ENA
GenomicsHomo sapiens
Evaluation of the NUP98-HOXA9 role as oncogenic transcription factor
PRJNA264478 | ENA
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