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ProteomicsRb and the APC/C coactivator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells
Cyclin dependent kinase 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry, at least in part through phosphorylation of the retinoblastoma tumor suppressor protein (Rb). The CDK4/6-cyclin D-Rb pathway is commonly deregulated in human cancer, often through CDK4/6 or D-type cycli...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2016-07-05 | PXD001501 | Pride
Lin-35 fzr1 
TranscriptomicsEffects of fzr1 knockdown on senescence-associated gene expression in human diploid fibroblasts.
Analysis of gene expression profile in Ras-induced senescent human diploid fibroblasts with or without depletion of fzr1/cdh1. Results provide insight into the effect on fzr1/cdh1 on the regulation of senescence-associated gene expression in human diploid fibroblasts. IMR-90-ER:Ras cells were cultu...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-30790 | biostudies-arrayexpress
GenomicsN6-methyladenosine modification of FZR1 mRNA promotes gemcitabine resistance in pancreatic cancer
N6-methyladenosine modification of FZR1 mRNA promotes gemcitabine resistance in pancreatic cancer
PRJNA853158 | ENA
OtherN6-methyladenosine modification of FZR1 mRNA promotes gemcitabine resistance in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with limited therapeutic options, and gemcitabine insensitivity remains a major challenge. N6-methyladenosine (m6A) is a prevalent nucleotide modification in mRNA that has been linked to various biological processes in human diseases,...
ORGANISM(S): Homo sapiens 
2023-06-08 | GSE206969 | GEO
GenomicsThe Fzr1-mediated early embryo stress response impairs fetal growth and metabolic reprogramming of offspring
The Fzr1-mediated early embryo stress response impairs fetal growth and metabolic reprogramming of offspring
PRJNA756909 | ENA
GenomicsN6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [m6A-seq]
N6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [m6A-seq]
PRJNA853161 | ENA
Methylation profilingN6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [m6A-seq]
Herein, by detecting the global m6A profile in a panel of gemcitabine-sensitive and gemcitabine-insensitive PDAC cells, we identified the key role of hyper-m6A modification of the master G0/G1 regulator Fizzy and Cell Division Cycle 20 Related 1 (FZR1) in regulating gemcitabine sensitivity. Targetin...
ORGANISM(S): Homo sapiens 
2023-06-09 | GSE206968 | GEO
GenomicsN6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [PAR-CLIP-Seq]
N6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [PAR-CLIP-Seq]
PRJNA853162 | ENA
OtherN6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [PAR-CLIP-Seq]
Herein, by detecting the global m6A profile in a panel of gemcitabine-sensitive and gemcitabine-insensitive PDAC cells, we identified the key role of hyper-m6A modification of the master G0/G1 regulator Fizzy and Cell Division Cycle 20 Related 1 (FZR1) in regulating gemcitabine sensitivity. Targetin...
ORGANISM(S): Homo sapiens 
2023-06-09 | GSE206967 | GEO
UnknownFZR1 as a novel biomarker for breast cancer neoadjuvant chemotherapy prediction.
Not available
S-EPMC7519164 | biostudies-literature
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