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TranscriptomicsHematopoietic stem cells from mice treated with G-CSF or saline alone for 36 hours
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte-colony stimulating factor (G-CSF) is often induced with infection and plays a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show tha...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-55093 | biostudies-arrayexpress
TranscriptomicsAMD3100 and G-CSF Mobilize Different CD34+ Cell Populations Based on Gene and miRNA Expression
Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF....
ORGANISM(S): Macaca mulatta 
2009-12-04 | E-GEOD-16936 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human G-CSF-mobilized Peripheral Blood Stem Cell Allograft
Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-7400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells from bone marrow and G-CSF-mobilized peripheral blood to investigate why the latter are optimal for allogeneic transplant recipients
Comparison of gene expression in CD34+ cells from bone marrow and G-CSF-mobilized peripheral blood to investigate why the latter are optimal for allogeneic transplant recipients.
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-500 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression of granulocytes during in vivo G-CSF/dexamethasone mobilization.
Treatment of healthy donors with G-CSF and dexamethasone, results in sufficient number of circulating granulocytes to prepare granulocyte concentrates for clinical purposes. Granulocytes obtained this way demonstrate relatively normal functional behavior combined with a prolonged life span. To study...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12841 | biostudies-arrayexpress
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression during G-CSF-induced emergency granulopoiesis in humans
Emergency granulopoiesis refers to the increased production of neutrophils in bone marrow and their release into circulation induced by severe infection. Several studies point to a critical role for granulocyte colony-stimulating factor (G-CSF) as the main mediator of emergency granulopoiesis. Howev...
ORGANISM(S): Homo sapiens 
2017-04-04 | E-MTAB-4668 | biostudies-arrayexpress
TranscriptomicsTumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism
Global gene expression studies were performed to determine whether the granulocytic-like MDSC populations from G-CSF treated mice resembled those of tumor-bearing (TB) mice more so than those of the non-tumor-bearing control (i.e., WT) at a molecular level. Splenic CD11b+Gr-1high cell populations fr...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-32209 | biostudies-arrayexpress
TranscriptomicsMurine Bone Marrow Stromal Cell Response to Granulocyte Colony-Stimulating Factor
Neutrophil homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal for neutrophils in the bone marrow through activation of its receptor CXCR4. Her...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-22925 | biostudies-arrayexpress
TranscriptomicsG-CSF mobilizes CD34+ regulatory monocytes that inhibit Graft-versus-Host Disease
Administration of G-CSF mobilizes a unique population of CD11b+Ly6C+CD34+mature monocytes that can inhibit GVHD in murine models of BMT via an iNOS-dependent mechanism. The transcriptional profiles of flow sorted lineage-CD11b+CD34+ cells from G-CSF treated mice were compared with conventional sple...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-65670 | biostudies-arrayexpress
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