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ProteomicsAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 to remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a new activator, Tma23, and a characterized activator, Pxr1, uncovered segments that organize Prp43 fun...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-10-09 | PXD046892 | Pride
Ribosome assembly Prp43 Cryo-em Hdx-ms Rna helicase 
ProteomicsThe G-patch protein Cwf28 interacts with the RNA helicase Cdc28 in catalytically active spliceosomes in Schizosaccharomyces pombe
G-patch proteins are emerging as key regulatory cofactors of DEAH-box RNA helicases involved in pre-mRNA splicing, yet the functions of many family members remain poorly understood. Here, we characterize the conserved G-patch domain–containing protein Cwf28 from Schizosaccharomyces pombe, an essenti...
ORGANISM(S): Schizosaccharomyces pombe 
2026-08-24 | PXD080271 | Pride
Cwf28  g-patch protein  rna helicase cdc28  pre-mrna splicing  schizosaccharomyces pombe 
ProteomicsAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 (DHX15 in humans) to productively remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a new activator, Tma23, and a characterized activator, Pxr1, uncovered s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-09 | PXD048382 | Pride
Ribosome assembly Mass spectrometry Prp43 Rna helicase 
ProteomicsProteomic analysis of Mason-Pfizer monkey virus virions
To accomplish their replication cycle, retroviruses rely heavily on a wide variety of cellular proteins and enzymes, such as helicases. Among these, the DExD-box and DEAH/RHA-box helicases were identified to play crucial roles in their nucleic acid metabolism. This study explores the Betaretrovirus ...
ORGANISM(S): Mason-Pfizer monkey virus 
2024-09-13 | PXD046672 | Pride
Mason-pfizer monkey virus Dhx15 G-patch domain Hek 293 Lc-ms/ms 
UnknownRegulation of DEAH/RHA helicases by G-patch proteins.
Not available
S-EPMC4322301 | biostudies-literature
UnknownStructural basis for DEAH-helicase activation by G-patch proteins.
Not available
S-EPMC7132122 | biostudies-literature
UnknownG-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.
Not available
S-EPMC3179746 | biostudies-literature
UnknownAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly.
Not available
S-EPMC11584650 | biostudies-literature
UnknownThe ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis.
Not available
S-EPMC2797057 | biostudies-literature
UnknownDefining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast <i>Schizosaccharomyces pombe</i>.
Not available
S-EPMC9658070 | biostudies-literature
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