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ProteomicsTo identify key DHX15 R222G-interacting proteins with differential binding affinity with the WT protein by co-immunoprecipitation (co-IP) and mass spectrometry in Kasumi-1 cells overexpressing either DHX15 WT or R222G.
To identify key DHX15 R222G-interacting proteins with differential binding affinity with the WT protein by co-immunoprecipitation (co-IP) and mass spectrometry in Kasumi-1 cells overexpressing either DHX15 WT or R222G.
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD068678 | Pride
Dhx15 r222g-interacting proteins 
ProteomicsA helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
DHX15 has been implicated in RNA splicing and ribosome biogenesis, primarily functioning as an RNA helicase. To systematically assess the cellular role of DHX15, we conducted proteomic analysis to investigate the landscape of DHX15 interactome, and identified MYC as a binding partner. DHX15 co-local...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046692 | Pride
Protein stability Dhx15 Leukemia Myc Rna helicase 
GenomicsRNAseq of DHX15-silenced endothelial cells
RNAseq of DHX15-silenced endothelial cells
PRJNA759857 | ENA
ProteomicsThe loss of the RNA helicase Dhx15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
DHX15 is an ATP-dependent RNA helicase involved in pre-mRNA splicing. We have recently reported that DHX15 is a downstream substrate for Akt1, which plays a significant role in vascular biology. Therefore, we aimed to explore the regulatory function of DHX15 over the vasculature, and the endothelial...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD018104 | Pride
Ltq-orbitrap fusion lumos 
GenomicsDHX15 regulates CMTR1-dependent gene expression and cell proliferation
DHX15 regulates CMTR1-dependent gene expression and cell proliferation
PRJNA453131 | ENA
GenomicsRNA helicase DHX15 exemplifies a unique dependency in acute leukemia
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia
PRJNA860939 | ENA
GenomicsA helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
PRJNA1040205 | ENA
UnknownCircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop.
Not available
S-EPMC10131429 | biostudies-literature
UnknownDHX15 inhibits mouse APOBEC3 deamination.
Not available
S-EPMC11990775 | biostudies-literature
UnknownDHX15 overexpression suppresses colorectal cancer cell line proliferation.
Not available
S-EPMC12863016 | biostudies-literature
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