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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
GenomicsG-quadruplex stabilization
The effect of prolonged G-quadruplex stabilization on the functions of human cells
PRJEB85998 | ENA
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
ProteomicsComprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5’ UTR of tumor-associated mRNAs
G-quadruplex structures in the 5’ UTR of mRNAs are widely considered to suppress translation without affecting transcription. The current study describes the comprehensive analysis of proteins binding to four different G-quadruplex motifs located in mRNAs of the cancer-related genes Bcl-2, NRAS, MMP...
ORGANISM(S): Homo sapiens (Human) 
2017-11-14 | PXD005761 | Pride
Nras Cancer Translational regulation Silac Mmp16 Rna Rbps Shotgun proteomics G-quadruplexes Bcl-2 Arpc2 Post-transcriptional regulation 
ProteomicsNon-canonical RNA-binding of the histone lysine demethylase KDM5 through interactions with G-quadruplex sequences
RNA-binding proteins are important regulators of RNA biogenesis and function, and recent work shows that chromatin- and RNA-binding proteins can have regulatory roles in transcription. Several approaches have been developed to predict RNA-binding proteins and to identify them experimentally at large...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD050767 | Pride
Histone lysine demethylase kdm5  g-quadruplex  non-canonical rna-binding 
GenomicsGenomic G-Quadruplex folding and unfolding following global DNA demethylation
Genomic G-Quadruplex folding and unfolding following global DNA demethylation
PRJNA804153 | ENA
ProteomicsMultistep mechanism of G-quadruplex resolution during DNA replication
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that a...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-17 | PXD027623 | Pride
G4 resolution G-quadruplex Helicases Dhx36 G4 Fancj Dna replication 
GenomicsProfiling DNA G-quadruplex structures at single-cell level
Profiling DNA G-quadruplex structures at single-cell level
PRJNA751854 | ENA
GenomicsIdentification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
Identification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
PRJNA1273212 | ENA
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