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MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
TranscriptomicsThe G1 arrest and maintenance mechanism between the long-term G1-arrested and the G1-arrested cells.
Non mitotic tumor cells are resistant to conventional chemotherapeutic drugs. However, the mechanisms underlying this phenomenon remain unclear. Here, we found a population that is viable but remains in the G1 phase for an extended period of time (up to 48 h) by Long-term time-lapse observations in ...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-61088 | biostudies-arrayexpress
ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
ModelsMoreno2019 - Stochastic model of G1 arrest due to proteostasis decline delimits replicative lifespan in yeast
This model is described within the paper: A G1 arrest due to proteostasis decline delimits replicative lifespan in yeast David F. Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikász-Nagy, Martí Aldea To be implemented in Copasi. Missing Event due to difficulties in SBML conver...
2019-11-29 | MODEL1901210001 | BioModels
TranscriptomicsLack of G1 cyclin arrest cell cycle synchronization time-course microarray in Glucose
Lack of G1 cyclin arrest cln1,2,3-delta MET3pr-CLN2 cells Cell cycle syncronization time-course microarray in Glucose. Time-course experiment. Samples are hybridized onto the first timepoint.
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-11 | E-GEOD-29800 | biostudies-arrayexpress
TranscriptomicsGene expression changes initiated by miR-34c in Dicer/Pten double knockout mouse serous epithelial cancer
miR-34c inhibits Dicer/Pten double knockout mouse serous epithelial cancer cell proliferation by inducing cell cycle arrest and apoptosis. We found that miR-34c had a more dramatic effect on inhibiting tumor cell viability than let-7b. The action of miR-34c induced tumor cell cycle arrest in G1 phas...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-57493 | biostudies-arrayexpress
ProteomicsOncogenic signals prime cancer cells for toxic cell growth during a G1 cell cycle arrest
A long-term goal in cancer research has been to inhibit the cell cycle in tumour cells without causing toxicity in proliferative healthy tissues. The best evidence that this is achievable is provided by CDK4/6 inhibitors, which arrest the cell cycle in G1, are well-tolerated in patients, and are eff...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD043792 | Pride
Oncogenic G1 Cell cycle Cancer 
TranscriptomicsMicroRNA expression during cell cycle arrest
The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or down-regulated in many types of cancers. Here we report the reciprocal relationship - that of the cell cycle controlling the miR-16 family...
ORGANISM(S): Mus musculus 
2011-09-15 | E-GEOD-31225 | biostudies-arrayexpress
TranscriptomicsGenes Predictive of G1 arrest in Melanoma Cell Lines
Transcriptional profiling of human melanoma cell lines to identify a G1 arrest signature Percentage of cells that arrest in G1 after irradiation was used to identify genes predictive of response
ORGANISM(S): Homo sapiens 
2012-08-13 | E-GEOD-40047 | biostudies-arrayexpress
TranscriptomicsBET Protein Inhibitor JQ1 Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines and animal models. Recently, a potential anticancer agent, JQ1, an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-70577 | biostudies-arrayexpress
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