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ProteomicsComparative proteomics identifies different metabolic pathways activated by p53 mutants G245S and R337H associated with Li-Fraumeni syndrome
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition disorder associated with germline mutations in the TP53 tumor suppressor gene. The p53 mutation spectrum associated with LFS is similar to that found in somatic tumors, with most of them, such as the G245S mutation, occurring in the DN...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD025056 | Pride
Metabolism Oxidative phosphorylation Li-fraumeni syndrome R337h Respiration Cancer cells G245s Tp53 Glycolysis Mutation 
UnknownVirtual screening using covalent docking to find activators for G245S mutant p53.
Not available
S-EPMC6128461 | biostudies-literature
UnknownInsights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA.
Not available
S-EPMC6152093 | biostudies-literature
UnknownTwo hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.
Not available
S-EPMC3679454 | biostudies-literature
UnknownDistinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity.
Not available
S-EPMC7555626 | biostudies-literature
UnknownSpecific TP53 mutations impair the recruitment of 53BP1 to DNA double-strand breaks underlying the mechanism of radioresistance.
Not available
S-EPMC12678470 | biostudies-literature
UnknownMechanism of rescue of common p53 cancer mutations by second-site suppressor mutations.
Not available
S-EPMC305574 | biostudies-literature
TranscriptomicsReactivation of mutant p53 by SLMP53-2: a promising therapeutic option against hepatocellular carcinoma
In order to pursue the search for new reactivators of mutant p53, a small library of molecules was synthesized starting from a previously established lead (SLMP53-1). The molecules were tested in various cell-based assays and one, herein referred to as SLMP53-2, displayed a marked reduction of the I...
ORGANISM(S): Homo sapiens 
2020-04-13 | GSE124021 | GEO
UnknownMutant p53 binds RNA to drive mitochondrial dysfunction.
Not available
S-EPMC12642436 | biostudies-literature
TranscriptomicsMutant p53 binds RNA to drive mitochondrial dysfunction
Tumor suppressor protein 53 (p53) is a transcription factor that is deregulated in 50% of cancers. Often termed the guardian of the genome, p53 is responsible for maintenance of genomic stability, cell cycle arrest, DNA repair, senescence, and apoptosis. In cancer cells, deregulation of p53 often oc...
ORGANISM(S): Homo sapiens 
2026-06-21 | GSE335668 | GEO
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