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ProteomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. However, it is challenging to predict how ARID1A loss might impact on responses to cancer therapies because it participates in many different cellular pathways. G quadruplex (G4) binding ligands, such ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-15 | PXD063556 | Pride
G4 ligands Arid1a 
GenomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
PRJNA1255162 | ENA
TranscriptomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A, a subunit of the BAF chromatin remodeler, is frequently mutated in cancer. Predicting how ARID1A loss impacts cancer therapy response is challenging because it influences many cellular pathways. G quadruplex (G4) binding ligands, such as pyridostatin, show anticancer effects, but the genetic...
ORGANISM(S): Homo sapiens 
2025-08-13 | GSE295547 | GEO
UnknownExploring the Dispersion and Electrostatic Components in Arene-Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands.
Not available
S-EPMC10860144 | biostudies-literature
UnknownE. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands.
Not available
S-EPMC7337899 | biostudies-literature
GenomicsChemo- versus immuno-precipitation of G-quadruplex-DNA (G4- DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture
Chemo- versus immuno-precipitation of G-quadruplex-DNA (G4- DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture
PRJNA823482 | ENA
UnknownAssessing G4-Binding Ligands In Vitro and in Cellulo Using Dimeric Carbocyanine Dye Displacement Assay.
Not available
S-EPMC7961521 | biostudies-literature
GenomicsCharacterization of TASQ Ligands Capturing in vivo G4 Structures in Rice
Characterization of TASQ Ligands Capturing in vivo G4 Structures in Rice
PRJNA1109724 | ENA
GenomicsChemo- versus immuno-precipitation of G-quadruplex-DNA (G4- DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture
The reliability of the BG4-IP-seq protocol, along with the straightforward access to rice genomic DNA, makes this system ideal for comparing the pull-down efficiency of the antibody BG4 versus the small-molecular baits BioTASQ and BioCyTASQ. These two TASQs (for template-assembled synthetic G-quarte...
ORGANISM(S): Oryza sativa 
2023-08-10 | GSE200171 | GEO
UnknownThe multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations.
Not available
S-EPMC10320843 | biostudies-literature
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