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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
ProteomicsFunctional proteomics defines a PRC2-G9A interaction network and reveals ZNF518B as a G9A regulator
Not available
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2014-12-17 | MSV000078980 | MassIVE
ProteomicsIdentification of proteins stably associated with G9a/GLP (EHMT2/EHMT1) complex of histone methyltransferases
G9a (EHMT2) and the G9a-like protein GLP (EHMT1) form a stable G9a/GLP heterodimer in embryonic stem cells and function cooperatively to establish and maintain the abundant repressive H3K9me2 modification, in addition to modifying several non-histone proteins. The G9a-dependent H3K9me2 is implicated...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-16 | PXD003466 | Pride
Shotgun proteomics G9a/glp (ehmt2/ehmt1) complex Embryonic stem cells Histones Mouse Chromatin 
TranscriptomicsHistone H3K9 Methyltransferase G9a Represses PPARγ Expression and Adipogenesis [Affymetrix expression data]
PPARγ promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the mechanisms that control expression of these positive and negative master regulators of adipogenesis remain incompletely understood. By genome-wide histone methylation profiling in preadipocytes, we find that among gene...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-41456 | biostudies-arrayexpress
GenomicsA role for Widely Interspaced Zinc finger (WIZ) in retention of the G9a methyltransferase on chromatin
G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the bulk of cellular mono- and di-methylation on histone H3 lysine 9 (H3K9me1/me2). Widely Interspaced Zinc finger (WIZ) associates with the G9a/GLP protein complex, but its role in lysine methylation is poor...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-67317 | biostudies-arrayexpress
TranscriptomicsExpression data from knockdown of G9a in MDA-MB231 cells
G9a is an H3K9m2 methyltransferase, which is critical in controlling gene suppression and DNA methylation. We used microarray analysis to identify the target genes that are regulated by G9a in MDA-MB231 cells, in which E-cadherin is silenced. G9a expression was stably knocked-down in MDA-MB231 cells...
ORGANISM(S): Homo sapiens 
2012-01-07 | E-GEOD-34925 | biostudies-arrayexpress
ProteomicsDe novo heterozygous variants in EHMT2 cause a novel Kleefstra related syndrome via loss of G9a methyltransferase activity
EHMT1 and EHMT2 genes encode human euchromatin histone lysine methyltransferase 1 and 2 (EHMT1 alias GLP; EHMT2 alias G9a) that form heteromeric GLP/G9a complexes with essential roles in epigenetic regulation of gene expression. While EHMT1 haploinsufficiency has been established as the cause of Kle...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD076523 | Pride
Ehmt2 Kleefstra syndrome 1 G9a proteins Ehmt1 
GenomicsHistone H3K9 Methyltransferase G9a Represses PPAR? Expression and Adipogenesis [ChIP-Seq and RNA-Seq data]
PPAR? promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the mechanisms that control expression of these positive and negative master regulators of adipogenesis remain incompletely understood. By genome-wide histone methylation profiling in preadipocytes, we find that among gene...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-41455 | biostudies-arrayexpress
TranscriptomicsH3K9me3 abcam.D.mel 3rd Instar Larvae Nuclei G9a mutant.Affy 2
modENCODE_submission_5611 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modificat...
ORGANISM(S): Drosophila melanogaster 
2013-03-13 | E-GEOD-45102 | biostudies-arrayexpress
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