Sort   by:  
 Page size 
ProteomicsChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes
Interleukin-2 (IL-2) stimulation results in T-cell growth as a consequence of activation of highly sophisticated and fine-tuned signaling pathways. Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, div...
ORGANISM(S): Homo sapiens (Human) 
2016-04-11 | PXD003286 | Pride
Scaffold protein T-lymphocytes Phosphorylation Il-2 Gab2 Interactome 
TranscriptomicsDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1
Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinical problem in CML, and TKI therapy is much less eff...
ORGANISM(S): Mus musculus 
2016-01-17 | E-GEOD-75615 | biostudies-arrayexpress
GenomicsTranscriptomic differences in murine AML bone marrow samples with different Gab2 genotypes
Transcriptomic differences in murine AML bone marrow samples with different Gab2 genotypes
PRJNA757092 | ENA
GenomicsToxoplasma gondii GAB2-2007-GAL-DOM2
Deep sequencing diverse lineages of Toxoplasma gondii.
PRJNA80767 | ENA
ProteomicsChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes
Interleukin-2 (IL-2) stimulation results in T-cell growth as a consequence of activation of highly sophisticated and fine-tuned signaling pathways. Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, div...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080707 | MassIVE
TranscriptomicsDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1
Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinical problem in CML, and TKI therapy is much less eff...
ORGANISM(S): Mus musculus 
2016-01-17 | GSE75615 | GEO
UnknownLinking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology.
Not available
S-EPMC3665686 | biostudies-literature
TranscriptomicsTranscriptomic differences in murine AML bone marrow samples with different Gab2 genotypes
Internal tandem duplications (ITD) of FLT3 predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In a genetically modified mouse model harboring these genetic aberrations, we analyzed the role of the adaptor protein Gab2 in this disease. We obs...
ORGANISM(S): Mus musculus 
2022-04-27 | GSE182624 | GEO
TranscriptomicsGenome functional screening identifies GAB2 as a key promoter of anchorage independence in normal and neoplastic cells
Acquisition of independence from anchorage to the extracellular matrix is a critical event for onset and progression of solid cancers. To identify and characterize new genes conferring anchorage independence, we transduced MCF10A human normal breast cells with a retroviral cDNA expression library an...
ORGANISM(S): Mus musculus Homo sapiens 
2009-10-21 | GSE18237 | GEO
UnknownAbnormal hematopoiesis in Gab2 mutant mice.
Not available
S-EPMC1896106 | biostudies-literature
Sort   by:  
 Page size