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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
MetabolomicsOverexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

Drought represents a major threat to food security. Mechanistic data describing plant responses to drought have been studied extensively and genes conferring drought resistance have been introduced into crop plants. However, plants with enhanced drought resistance usually display lower growth, hi...

2021-05-17 | MTBLS2289 | MetaboLights
MetabolomicsThe alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Heart raw data
Not available
ORGANISM(S): Mus musculus 
ST000451 | MetabolomicsWorkbench
MetabolomicsThe alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Serum raw data
Not available
ORGANISM(S): Mus musculus 
ST000452 | MetabolomicsWorkbench
Transcriptomicsler vs pop2-1: gaba over-accumulation effects-Transcriptomic analysis of pop2-1 mutant in Arabidopsis thaliana
au05-03_gaba - ler vs pop2-1: gaba over-accumulation effects - The analysis aims at identifying genes that are differentially regulated by the over-accumulation of GABA observed in the mutant pop2-1 in response to treatment with exogenous GABA and that may explain the singular phenotype of the mutan...
ORGANISM(S): Arabidopsis thaliana 
2009-04-11 | E-GEOD-11129 | biostudies-arrayexpress
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
ProteomicsPhosphoproteomic analysis supporting structural basis for GABAA receptor pi activation
GABAA receptors (GABAAR) are pentameric chloride channels comprising various combinations of different subunits that are activated by γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in vertebrates. we show here that GABRP chloride channel activity and ERK signaling is directly regul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD044482 | Pride
Phosphoproteomics Dia Gabaa receptor 
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
GenomicsRepositioning of a GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of Non-Alcoholic Steatohepatitis
Repositioning of a GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of Non-Alcoholic Steatohepatitis
PRJNA740033 | ENA
TranscriptomicsExpression changes in IC GABA receptors in the auditory midbrain of young adult and aging presbycusis mice.
We performed a microarray analysis of auditory midbrain (inferior colliculus, IC) mRNA from young adult CBA mice (controls) with good hearing, middle aged (MA) with good hearing, and old mild (MP) and severe (SP) presbycusic CBA mice. Fold Change data derived from RMA normalization revealed that the...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-49522 | biostudies-arrayexpress
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