Gabaergic synapse

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Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
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CHEBI ID

CHEBI:45979 (1)
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CHEBI:81281 (1)
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CHEBI:10070 (1)
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CHEBI:67118 (1)
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CHEBI:27585 (1)

Metabolite Name

D-Xylose (1)
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IsPrivate

False (1)

First Public Date

2025 (9)
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Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (19)
Animal - High-throughput sequencing (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of coding RNA (2)
Unknown experiment type (1)
CLIP-seq (1)

Release Date

2022 (54)
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Lab affiliation

Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, No. 8, Longyuan Road, Nanshan District, Shenzhen, 518055, China. Tel: +86 75525601914, Fax: +86 75525508584 (1)
Institut du Fer a Moulin, Inserm-Sorbonne Université UMR-S 1270, Paris, France (1)
Dept of Neurology University Hospital RWTH Aachen Pauwelsstrasse 30 52074 Aachen Germany (1)
Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, Australia (1)
Department of Quantitative Biomedicine, University of Zurich, Switzerland (1)
Synapse Development and Plasticity Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Quebec, H2W 1R7, Canada Integrated Program in Neuroscience, McGill University, Montreal, Quebec, H3A 2B2, Canada Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada Division of Experimental Medicine, McGill University, Montreal, Quebec, H3A 0G4, Canada (1)
Centre de Recherche en Cancérologie de Marseille Inserm UMR1068, CNRS UMR7258, Aix-Marseille Université UM105,Institut Paoli-Calmettes 13273 MARSEILLE FRANCE (1)
1. CERVO Brain Research Centre, Quebec Mental Health Institute; Québec, QC, G1E 1T2, Canada. 2. Department of Psychiatry & Neuroscience, Université Laval; Québec, QC, G1V 0A6, Canada. (1)
Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. (1)
Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, and PKU International Cancer Institute, Peking University Health Science Center, #38 Xue Yuan Road, Beijing 100191, China. (1)
Institute of Physiology II, Universität Freiburg, Germany (1)
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Department of Neurology, Johns Hopkins University (1)
Faculty of Health Sciences, Department of Proteomics, The Novo Nordisk Foundation Centre for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark (1)
University of Basel, Biozentrum, Switzerland (1)
Texas Tech University Health Sciences Center - El Paso (1)

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Isolation of a Novel Rat Neural Progenitor Clone that Expresses Dlx Family Transcription Factors and Gives Rise to Functional GABAergic Neurons in Culture

GABAergic interneurons are lost in conditions including epilepsy and CNS injury, but there are few culture models available to study their function. Towards the goal of obtaining renewable sources of GABAergic neurons, we used the molecular profile of a functionally-incomplete GABAergic precursor c...

ORGANISM(S): Rattus norvegicus

2011-11-09 | E-GEOD-31635 | biostudies-arrayexpress

Rapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming

Transplantation of GABAergic interneurons (INs) can sustain long-standing benefits in animal models of epilepsy and other neurological disorders. In a therapeutic perspective, a renewable source of functional GABAergic INs is needed. Here, we identified five factors (Foxg1, Sox2, Ascl1, Dlx5 and Lhx...

ORGANISM(S): Mus musculus

2015-12-15 | E-GEOD-74065 | biostudies-arrayexpress

Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.

Not available

S-EPMC5957482 | biostudies-literature

Genetic Deletion of GABA_A Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development.

Not available

S-EPMC6558517 | biostudies-literature

Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum

PRJNA720923 | ENA

Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation.

Not available