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TranscriptomicsKMT2D haploinsufficiency in Kabuki Syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation
Kabuki Syndrome (KS) is a multisystemic rare disorder, characterized by growth delay, distinctive facial features, intellectual disability, and rarely autism spectrum disorder. This condition is mostly caused by de novo mutations of KMT2D, encoding a catalytic subunit of the COMPASS complex involved...
ORGANISM(S): Homo sapiens 
2022-12-25 | E-MTAB-10244 | biostudies-arrayexpress
TranscriptomicsThe Antarctic Krill Euphausia superba Shows Diurnal Cycles of Transcription under Natural Conditions.
BACKGROUND: Polar environments are characterized by extreme seasonal changes in day length, light intensity and spectrum, the extent of sea ice during the winter, and food availability. A key species of the Southern Ocean ecosystem, the Antarctic krill (Euphausia superba) has evolved rhythmic physio...
ORGANISM(S): Euphausia superba 
2013-07-23 | E-GEOD-42292 | biostudies-arrayexpress
TranscriptomicsCell reprogramming requires silencing of a core subset of Polycomb targets.
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been proposed as a defining mark that distinguishes the ...
ORGANISM(S): Mus musculus 
2013-03-09 | E-GEOD-44972 | biostudies-arrayexpress
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
TranscriptomicsIdentification of the 5' end of the pig miRNA by the RAKE technology
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28139 | biostudies-arrayexpress
TranscriptomicsIdentification of the 3' end of the pig miRNA by the RAKE technology [platform 1: 9003467]
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28137 | biostudies-arrayexpress
TranscriptomicsIdentification of the 3' end of the pig miRNA by the RAKE technology [platform 2: 9003179]
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28138 | biostudies-arrayexpress
TranscriptomicsMessenger RNA transcript expression in the pig (S. scrofa)
90K Combimatrix gene expression microarrays were composed by 17,048 replicated probes and 963 not replicated specific for the Ensembl (Ver. 56) Transcripts (protein coding + pseudogenes + retrotransposed elements), 11,363 replicated probes specific for the UniGene clusters (Ver. 38) of length compri...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-27853 | biostudies-arrayexpress
UnknownCardiac surgery practice during the COVID-19 outbreak: a multicentre national survey.
Not available
S-EPMC7989504 | biostudies-literature
TranscriptomicsEvaluation of miRNA expression in 14 different tissues by the RAKE technology
The short length of miRNAs results in a high dynamic range of melting temperatures and therefore impedes a proper selection of detection probes or optimized PCR primers. While miRNA microarrays allow for massive parallel and accurate relative measurement of all known miRNAs, they have so far been le...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28140 | biostudies-arrayexpress
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