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ProteomicsEarly Cardiac Proteomic Profiling in a Long-Latency Doxorubicin Cardiomyopathy Model Exhibits Sexual Dimorphism for Cardioprotection
In this study, we employed large-scale data-independent acquisition (DIA) proteomics in a long-latency rat model of doxorubicin-induced cardiomyopathy to characterize early cardiac proteomic remodeling prior to overt functional decline. Male and female Sprague-Dawley rats received a cumulative low d...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD076815 | Pride
Doxorubicin Dia Proteomics Female Long latency Male Data-independent acquisition Cardiomyopathy 
TranscriptomicsSex differences during acute myocarditis against coxsackievirus B3 (CVB3)-induced myocarditis (10 dpi) and chronic myocarditis/dilated cardiomyopathy (DCM) against CVB3-induced myocarditis (90 dpi)
Men are at an increased risk of dying from heart failure caused by inflammatory heart diseases such as atherosclerosis, myocarditis and dilated cardiomyopathy (DCM). We previously showed that immune responses in the heart are phenotypically distinct in male compared to female mice 10 days after infe...
ORGANISM(S): Mus musculus 
2012-01-19 | E-GEOD-35182 | biostudies-arrayexpress
TranscriptomicsThe study of sex differences during the innate immune response against coxsackievirus B3 (CVB3)-induced myocarditis (12hr post infection)
Men are at an increased risk of dying from heart failure caused by inflammatory heart diseases such as atherosclerosis, myocarditis and dilated cardiomyopathy (DCM). We previously showed that macrophages in the spleen are phenotypically distinct in male compared to female mice at 12 hours (h) after ...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26630 | biostudies-arrayexpress
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