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ProteomicsStructure and dynamics of GAD65 and its interaction with the autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11.
The enzyme glutamate decarboxylase (GAD) produces the neurotransmitter GABA, using pyridoxal-5’-phosphate. GAD exists as two isoforms, GAD65 and GAD67. Only GAD65 acts as a major autoantigen, with its autoantibodies frequently found in type 1 diabetes and other autoimmune diseases. Here we character...
ORGANISM(S): Homo sapiens (Human) 
2025-02-08 | PXD056756 | Pride
B96.11 Gad65 
TranscriptomicsResponse of peripheral blood mononuclear cells to west nile virus (E, NS2a) and type 1 diabetogenic antigens (GAD65, ZnT8) derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 3 healthy donors. The cells ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72372 | biostudies-arrayexpress
GenomicssnRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis
snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis
PRJNA1297713 | ENA
TranscriptomicsResponse of peripheral blood mononuclear cells from 15 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (GAD65, IGRP, PPI, ZnT8) and influenza virus M derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 15 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72376 | biostudies-arrayexpress
TranscriptomicssnRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis
Autoantibodies (ABs) against intracellular proteins, including glutamate-decarboxylase 65 (anti-GAD65), are increasingly recognized in autoimmune and limbic encephalitis (AE/LE). Anti-GAD65 LE frequently progresses into severe temporal lobe epilepsy (TLE), neuropathologically characterized by hippoc...
ORGANISM(S): Homo sapiens 
2026-07-09 | GSE303810 | GEO
UnknownElevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
Not available
S-EPMC4468815 | biostudies-literature
UnknownRegulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment.
Not available
S-EPMC3459802 | biostudies-literature
UnknownEpigenetic suppression of GAD65 expression mediates persistent pain.
Not available
S-EPMC3210928 | biostudies-literature
UnknownPalmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.
Not available
S-EPMC4646170 | biostudies-literature
UnknownAscending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding.
Not available
S-EPMC4046268 | biostudies-literature
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