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TranscriptomicsExpression profile of human ESC, ESC-drived definitive endoderm and endodermal progenitor cells
Endodermal progenitor cells (EP cells) are derived from human embryonic stem cell(ESC)-derived definitive endoderm (DE) cells. EP cells are cultured in high BMP media and DE cells are in high Activin media. Both cells can be further differentiated to liver, pancreas, etc. We used microarray to detai...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-35461 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of mouse Gata1- megakaryocyte-erythroid progenitors (G1MEs) expressing one of the two isoforms of GATA1: full-length (GATA1fl) or an amino-truncated form of GATA1 (GATA1s).
We transduced mouse Gata1- megakaryocyte-erythroid progenitors with MIGRI-GFP vector expressing GATA1fl or GATA1s cDNAs. GFP-positive cells expressing one of the two isoforms of GATA1 were isolated by FACS 42 hours following transduction and used for microarray transcriptome analysis. At this time p...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-62879 | biostudies-arrayexpress
TranscriptomicsInducible Gata1 Suppression Expands Erythro-Megakaryocytic Progenitors from Embryonic Stem Cells
Embryonic stem (ES) and induced pluripotent stem (iPS) cells represent a potential source of megakaryocytes and platelets for transfusion therapies. However, most current ES/iPS cell differentiation protocols are limited by low yields of hematopoietic progeny. Mutations in the mouse and human genes ...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-66479 | biostudies-arrayexpress
UnknownChromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.
Not available
S-EPMC7856552 | biostudies-literature
TranscriptomicsMouse embryonic and induced pluripotent stem cells can form definitive endoderm despite differences in imprinted genes
The directed differentiation of induced pluripotent stem (iPS) and embryonic stem (ES) cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal tissues. However, a global comparison of the relative equivalency of DE derived from iPS and ES p...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-27087 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of trisomy 21 and euploid iPSC-derived hematopoietic progenitors expressing wtGATA1 or an amino-truncated isoform of GATA1, GATA1short (GATA1s).
We generated human induced pluripotent stem cells (iPSCs) from trisomy 21 (T21) and euploid patient tissues with and without GATA1 mutations causing exclusive expression of truncated GATA1, termed GATA1short (GATA1s). Transcriptome analysis comparing expression levels of genes in GATA1s vs. wtGATA1-...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-36787 | biostudies-arrayexpress
TranscriptomicsClonal Genetic and Hematopoietic Heterogeneity among Human Induced Pluripotent Stem Cell lines
Induced pluripotent stem cells hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed three separate iPS...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-49231 | biostudies-arrayexpress
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