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TranscriptomicsDevelopment of distinct gene expression signature in neurons from different regions of the brain
We have performed microarray expression profiling of mouse primary neurons (cortical neurons and granule cell neurons) to model molecular networks and define whether distinct antiviral IFN responses occurred in neurons corresponding to different brain regions. Primary mouse cortical neurons and gran...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-42727 | biostudies-arrayexpress
UnknownLong double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN.
Not available
S-EPMC2885285 | biostudies-literature
TranscriptomicsA Mouse Model of Chronic West Nile Virus Infection
Here, we characterize the RIX line CC(032x013)F1, which serves as a mouse model of chronic WNV infection. While studies using C57BL/6 mice have shown that WNV RNA can persist in the CNS up to 3 months post infection in a limited fraction of mice (Appler et al., 2010), to date there is a lack of a ro...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-82046 | biostudies-arrayexpress
TranscriptomicsIRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response RPMI + rmGM-CSF purified bone marrow deriv...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-41355 | biostudies-arrayexpress
TranscriptomicsAddressing bias in small RNA library preparation for sequencing: a new protocol recovers microRNAs that evade capture by current methods
We performed deep sequencing of small RNA from mouse insulinoma (MIN6) cells or mouse liver using different library prepartion methods. Libraries were preapred using MIN6 or Mouse Liver total RNA using (1) Illumina v1.5 small RNA library prep kit, (2) Illumina TruSeq kit, or (3) Bioo Scientific NEXT...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-75457 | biostudies-arrayexpress
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownWarmth and competence perceptions of key protagonists are associated with containment measures during the COVID-19 pandemic: Evidence from 35 countries.
Not available
S-EPMC9732048 | biostudies-literature
UnknownLithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial.
Not available
S-EPMC8600458 | biostudies-literature
UnknownInternational Prospective Registry of Acute Coronary Syndromes in Patients With COVID-19.
Not available
S-EPMC8128002 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
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