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MetabolomicsUntargeted Serum Metabolomics Reveals Differential Signatures in Gallstone-Associated and Gallstone-Free Gallbladder Cancer

Gallbladder cancer (GBC) is an aggressive malignancy often associated with gallstones (GBCGS), a condition distinct from gallstone disease (GSD). Both GBC and GBCGS are rare, with unclear pathogenesis and no established biomarker-based solutions. This pilot study aimed to identify distinct metabo...

2025-12-22 | MTBLS12514 | MetaboLights
TranscriptomicsIdentification of circulating lncRNAs associated with gallbladder cancer risk by tissue-based preselection, cis-eQTL validation, and analysis of association with genotype-based expression
Long non-coding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here we integrate three separate datasets with information on lncRNA expression only, ...
ORGANISM(S): Homo sapiens 
2022-01-17 | E-MTAB-11367 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of gallbladder cancer
We carried out an iTRAQ-based quantitative proteomic analysis of gallbladder cancer and adjacent non-tumor tissue to systematically identify differentially expressed proteins in gallbladder cancer. Ten gallbladder adenocarcinoma and ten adjacent non-tumor tissue samples were selected post pathologic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082884 | MassIVE
TranscriptomicsLong noncoding RNAs and mRNAs expression analysis of gallbladder cancer
Although many protein-coding genes have been identified to be aberrantly expressed in gallbladder cancer, the mechanism that account for the development and progression of gallbladder cancer remains unclear. In recent years, long noncoding RNAs have been shown to play vital roles in mammalian cell b...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-62335 | biostudies-arrayexpress
TranscriptomicsMethylation analysis of Chilean patients with gallstone disesase, low- or high-grade gallbladder dysplasia or gallbladder cancer
Epigenome-wide methylation levels were measured in patients from Chiel with gallstone disease, gallbladder dyplasia or gallbladder cancer using Illumina Infinium methylation arrays.
ORGANISM(S): Homo sapiens 
2020-12-12 | E-MTAB-9868 | biostudies-arrayexpress
MetabolomicsDistinct Metabolomic and Lipoprotein signatures in Gall Bladder Cancer patients of Black African ancestry

Gallbladder cancer (GBC) is the most common biliary tract malignancy and is often diagnosed at advanced stages, partly due to the absence of reliable biomarkers and limited understanding of its biology in African populations. This study aimed to characterize the metabolomic and lipoprotein profil...

2025-09-05 | MTBLS12944 | MetaboLights
ProteomicsMacrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic targets can significantly improve clinical management of GBC. We carried out quantitative pr...
ORGANISM(S): Homo sapiens (Human) 
2015-10-02 | PXD001566 | Pride
Quantitative proteomics Targeted therapy Rna interference Gastrointestinal cancer Suicide substrate Bottom-up proteomics 
ProteomicsTranscriptome and phosphoproteome analyses of gemcitabine-resistant gallbladder cancer cells provide novel insights into molecular changes occurring during acquired resistance
Treatment options for advanced gallbladder cancer (GBC) are scarce and usually rely on cytotoxic chemotherapy, but unfortunately the effectiveness of any regimen is limited, and recurrence rates are high. Here, we established and characterized two gemcitabine-resistant GBC cell sublines (NOZ GemR an...
ORGANISM(S): Homo sapiens (Human) 
2023-05-03 | PXD036348 | Pride
Gemcitabine resistance Gallbladder cancer 
ProteomicsQuantitative proteomic analysis of gallbladder cancer
We carried out an iTRAQ-based quantitative proteomic analysis of gallbladder cancer and adjacent non-tumor tissue to systematically identify differentially expressed proteins in gallbladder cancer. Ten gallbladder adenocarcinoma and ten adjacent non-tumor tissue samples were selected post pathologic...
ORGANISM(S): Homo sapiens (Human) 
2015-06-26 | PXD000619 | Pride
Gallbladder cancer Transgelin Prosaposin Quantitative proteomics Biomarkers Itraq 
GenomicsGenentech study of gallbladder cancer
Genomic characterization of gallbladder cancer using Exome-Seq, RNA-Seq and low pass whole genome sequencing.
EGAS00001003004 | EGA
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