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ProteomicsNFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms spanning these different levels of organization remain elusive. From RNAi screens for mitochondrial biogenesis, we discovered NFYB-1, a subunit of the NF-Y transcriptional complex,...
ORGANISM(S): Caenorhabditis elegans 
2020-03-11 | PXD013233 | Pride
Nfyb-1 Mitochondria Proteomics Ceramide Metabolomics Cardiolipin Single shot Stress response Prosaposin Ageing Label-free Transcriptomics 
TranscriptomicsTranscription profiling of prosaposin deficient mice show molecular alterations precede neuronal deficits
Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipids hydrolases in lysosomes. To explore the molecular mechanism(s) of disease progression, temporal transcriptome microarray analyses of cerebrum and cerebellum tissues were conducted...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-8307 | biostudies-arrayexpress
GenomicsNFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
PRJNA525790 | ENA
TranscriptomicsExpression and neurobehavioral analyses in prosaposin deficient mice: Molecular alterations precede neuronal deficits
Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipids hydrolases in lysosomes. To explore the molecular mechanism(s) of disease progression, temporal transcriptome microarray analyses of cerebrum and cerebellum tissues were conducted...
ORGANISM(S): Mus musculus 
2008-08-08 | GSE8307 | GEO
TranscriptomicsNFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms spanning these different levels of organization remain elusive. From RNAi screens for mitochondrial biogenesis, we discovered NFYB-1, a subunit of the NF-Y transcriptional complex,...
ORGANISM(S): Caenorhabditis elegans 
2020-03-11 | GSE127917 | GEO
GenomicsProsaposin promotes neural stem cell quiescence
Prosaposin promotes neural stem cell quiescence
PRJNA999741 | ENA
UnknownRegulation of lysosomal trafficking of progranulin by sortilin and prosaposin.
Not available
S-EPMC8833632 | biostudies-literature
UnknownTemporal changes in prosaposin expression in the rat dentate gyrus after birth.
Not available
S-EPMC4037173 | biostudies-literature
UnknownProsaposin mediates inflammation in atherosclerosis.
Not available
S-EPMC8209679 | biostudies-literature
UnknownSevere vestibular dysfunction and altered vestibular innervation in mice lacking prosaposin.
Not available
S-EPMC3312039 | biostudies-literature
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