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GenomicsChIP-seq for PAX8 and histone modifications in Renal Cell Carcinoma cell lines.
In this experiment we analyzed the genome wide occupancy of PAX8 by ChIP-seq in four Renal Cell Carcinoma cell lines. Additionally we performed ChIP-seq also for histone modifications correlated with transcriptional activity (H3K27ac), enhancers (H3K4me1) and promoters (H3K4me3). Unrelated IgG was u...
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7812 | biostudies-arrayexpress
TranscriptomicsATAC-seq in Renal Cell Carcinoma cell lines
In this experiment we profiled the genome wide chromatin accessibility in 4 Renal Cell Carcinoma cell lines.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7844 | biostudies-arrayexpress
TranscriptomicsRNA-seq upon PAX8 knockdown in Renal Cell Carcinoma cell lines
In this experiment we examined the genes regulated by PAX8 knockdown in four renal cell carcinoma models. Four different cell lines bearing a validated doxycycline (DOX) inducible shRNA against PAX8 were treated with DOX for 96 hours and their gene expression profile analyzed by RNA-seq.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7808 | biostudies-arrayexpress
GenomicsGenomic and Proteomic Analyses of Prdm5 Reveal Interactions with Insulator Binding Proteins in Embryonic Stem Cells (ChIP-seq)
PRDM proteins belong to the SET domain protein family, which is involved in the regulation of gene expression. Although few PRDM members possess histone methyltransferase activity, the molecular mechanisms by which the other members exert transcriptional regulation remain to be delineated. In this s...
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-51816 | biostudies-arrayexpress
TranscriptomicsPrdm5 suppresses ApcMin-driven intestinal adenomas and regulates monoacylglycerol lipase expression
PRDM proteins are tissue specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high fre...
ORGANISM(S): Mus musculus 
2013-05-11 | E-GEOD-46821 | biostudies-arrayexpress
GenomicsThe Hippo tranducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation
The Hippo pathway effector YAP1 controls stem cell fate in epithelial tissues, but its role in stem cells of non-epithelial tissues, such as skeletal muscle, is poorly documented. Here we show that sustained YAP1 activity in mouse activated satellite cells in vivo induces rhabdomyosarcoma (RMS) rese...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-55186 | biostudies-arrayexpress
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