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ProteomicsBeyond Inhibition - Sub-lethal Rifampicin-induced molecular adaptations confer phenotypic drug tolerance in Mycobacteria
This study investigates how sub-lethal concentrations of rifampicin act as a signalling stimulus that induces phenotypic drug tolerance in mycobacteria. Using Mycobacterium smegmatis as a fast-growing model and validating findings in the attenuated Mycobacterium tuberculosis H37Ra strain, we examine...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Bacteria Mycobacterium tuberculosis H37Ra 
2026-06-08 | PXD075873 | Pride
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo sapiens (Human) 
2017-01-24 | PXD004241 | Pride
Proteomics Neuroblastoma Network analysis 
ProteomicsUncovering the metabolic pleiotropy of FMR1-deficiency in Fragile X Syndrome
ene pleiotropy defines the capacity of a gene to impact multiple phenotypic characters. The Fragile X Mental Retardation 1 (FMR1) gene is a candidate for pleiotropy, as it controls protein synthesis through its product, the translational regulator FMRP. As FMR1 loss-of-function leads to neurodevelop...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD007241 | Pride
Gene pleiotropy Mouse Fmr-1 Liver Fxs 
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
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