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MetabolomicsA Bidirectional Regulatory ACLY-NLRP3 Axis Integrates Metabolic and Inflammatory Signaling to Control NLRP3 Inflammasome Activation

The NLRP3 inflammasome is critical for host defense against bacterial infection and is involved in the pathogenesis of various inflammatory diseases. The aggregation of its sensor protein NLRP3 is a pivotal checkpoint for inflammasome activation. Howev...

2026-01-07 | MTBLS13400 | MetaboLights
ProteomicsTriglyceride induces ‌endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity
Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection‌. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to ampli...
ORGANISM(S): Mus Musculus 
2026-01-12 | PXD072975 |
MetabolomicsNLRP3 Senses L-Arginine to Inhibit Inflammasome Activation and Alleviate Parkinson’s disease Pathology

We screened a series of metabolites and found that L-Arg strongly inhibits NLRP3 inflammasome assembly in vitro. Mechanistically, L-Arg directly binds the D31 site of NLRP3, blocking NLRP3-ASC interaction and subsequent inflammasome assembly. This discovery establishes NLRP3 as a direct sensor fo...

2026-09-02 | MTBLS13737 | MetaboLights
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