Triglyceride induces endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity
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ABSTRACT: Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to amplify the SYK-associated antifungal signaling.
ORGANISM(S): Mus Musculus
SUBMITTER:
Chengjiang Gao
PROVIDER: PXD072975 | iProX | Mon Jan 12 00:00:00 GMT 2026
REPOSITORIES: iProX
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