Triglyceride induces endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Chengjiang Gao
PROVIDER: PXD072975 | iProX | Mon Jan 12 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity.
Wu Han H Shui Qing Q Luan Xiaoxi X Wang Kexin K Zhao Wei W Qi Xiaopeng X Liu Bingyu B Sun Wanwei W Gao Chengjiang C
Cell reports 20260211 2
Invasive fungal infections remain a major clinical challenge due to limited antifungal drugs, drug toxicity, and resistance. Fungal infections trigger endoplasmic reticulum (ER) stress. However, the mechanism through which this stress response affects antifungal immunity remains unclear. Here, we showed that de novo triglyceride synthesis promotes antifungal innate immune signaling and proinflammatory gene expression in macrophages. Upon fungal stimulation, triglycerides induce ER lipid bilayer ...[more]
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