Triglyceride induces ‌endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

ABSTRACT: Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection‌. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to amplify the SYK-associated antifungal signaling.

ORGANISM(S): Mus Musculus

SUBMITTER: Chengjiang Gao  

PROVIDER: PXD072975 | iProX | Mon Jan 12 00:00:00 GMT 2026

REPOSITORIES: iProX