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UnknownQingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways.
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S-EPMC4856955 | biostudies-literature
TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
GenomicsSorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells
The epithelial to mesenchymal transition (EMT) has been well recognized for many decades as an essential early step in the progression of primary tumors towards metastases. Widespread epigenetic reprogramming of DNA and histone modifications tightly regulates gene expression and cellular activity du...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-41479 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs and Their Target Genes in Peach (Prunus persica L.) Using High-Throughput Sequencing and Degradome Analysis
MicroRNAs play critical roles in various biological and metabolic processes. The function of miRNAs has been widely studied in model plants such as Arabidopsis and rice. However, the number of identified miRNAs and related miRNA targets in peach (Prunus persica) is limited. To understand further the...
ORGANISM(S): Prunus persica 
2014-01-01 | E-GEOD-49579 | biostudies-arrayexpress
GenomicsGenome-wide maps of Foxa2 binding sites in mouse embryonic stem cell-derived definitive endoderm cells
Foxa2 is required for endoderm differentiation into hepatic lineage. The mechanism of activation for Foxa2 during this developmental process has not been elucidated yet. We established an in vitro system to guide ES cells differentiating into definitive endoderm (DE) cells and the following DE cells...
ORGANISM(S): Mus musculus 
2012-08-29 | E-GEOD-40423 | biostudies-arrayexpress
ProteomicsTargeting CD37 promotes phagocytosis against multi cancer cell
Macrophages play vital roles in innate and adaptive immunity, and their indispensable functions are accomplished by phagocytosis and antigen presentation. Great efforts have been made to explore the potential mechanism of action of potential phagocytosis checkpoints. However, the use of a systematic...
ORGANISM(S): Homo Sapiens 
2025-06-04 | PXD061433 |
ProteomicsComprehensive analysis of individual variation in the urinary proteome revealed significant gender differences
To elucidate the individual variation and related factors influencing the urinary proteome, we comprehensively analyzed the urine samples from healthy adult donors (aged 20-69 years). Co-expression network analysis revealed protein clusters representing the metabolic status, gender-related differenc...
ORGANISM(S): Homo Sapiens 
2019-05-21 | PXD013949 |
ProteomicsIntegrated Analysis of Laminin Subunit Beta 1 Impact on Subchorionic Hemorrhage: Insights into Inflammation and Thrombosis Pathways
Subchorionic hemorrhage (SCH) is characterized by a fluid-filled hypoechoic area in early pregnancy. This study investigates how laminin subunit β1 (LAMB1) modulates type III collagen (COL3A1) and Rac family small GTPase 1 (RAC1) in SCH coagulation and immunity.
ORGANISM(S): Homo Sapiens 
2025-12-03 | PXD071504 |
ProteomicsNoninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis
Colorectal cancer is the 3rd commonly diagnosed cancer (10.2%) and 2nd cause of cancer death (9.2%) in all cancers.There will be estimated 1.8 million new colorectal cancer cases and 0.9 million colorectal cancer deaths in 20181. As the 5th incidence rates and mortality rates cancer in china, colore...
ORGANISM(S): Homo Sapiens 
2022-03-15 | PXD032291 |
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