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TranscriptomicsFine-tuning of human dendritic cells regulation revealed by translational profiling
Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in acco...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-14000 | biostudies-arrayexpress
Transcriptomicsarray-CGH profiling of human neuroblastoma samples obtained from infants included in the INES99.1, INES99.2 and INES99.3 trials
In neuroblastoma (NB), the presence of segmental chromosome alterations (SCA) is associated with a higher risk of relapse, even when occurring together with numerical chromosome alterations (NCA). Furthermore, recent evidence shows that SCAs play a role in tumor progression. In order to analyze the ...
ORGANISM(S): Homo sapiens 
2011-12-07 | E-GEOD-26494 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Effect of vehicle vs non-toxic and toxic paracetamol (151mg/kg and 529mg/kg) doses on the gene expression profile at 1, 4 and 24h in murine liver.
ORGANISM(S): Mus musculus 
2004-02-20 | E-MEXP-82 | biostudies-arrayexpress
UnknownOral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03).
Not available
S-EPMC8287271 | biostudies-literature
UnknownEfficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients.
Not available
S-EPMC8481292 | biostudies-literature
TranscriptomicsA general framework for optimization of probes for gene expression microarray and its application to the fungus Podospora anserina
A genome wide microarray, covering the 10546 presently known and predicted CDS, has been constructed with the Agilent in-situ synthesized 60-mers technology. 1) A library of 10 oligonucleotides per CDS has been design by the manufacturer. 2) A computational step has been performed to determine 3' po...
ORGANISM(S): Podospora anserina 
2010-06-30 | E-GEOD-20734 | biostudies-arrayexpress
TranscriptomicsHigh-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes
Inflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybri...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-23720 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress
TranscriptomicsIGR_CREMEC_CGH_STYDY_LL
Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and might be more relevant preclinical models to evaluate effective therapeutic agents. Our consortium joins efforts to extensively develop and characterize a new collection of patient-derived colorectal ...
ORGANISM(S): Homo sapiens 
2012-07-27 | E-MTAB-992 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of ERBB2-amplified breast cancers
15-25% of breast cancers (BC) show ERBB2-amplification and overexpression of the encoded ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better knowledge of these BCs may help understand their behavior and design new therapeutic stra...
ORGANISM(S): Homo sapiens 
2009-09-02 | E-GEOD-17907 | biostudies-arrayexpress
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