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TranscriptomicsTranscript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae
Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating betw...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-41094 | biostudies-arrayexpress
ProteomicsSex specific pertubations of neuronal development caused by mutations in the autism risk gene DDX3X
DDX3X is an X-linked RNA helicase that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and autism spectrum disorder (ASD) and are predominantly identified in females. Using cellular and mouse mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD060033 | Pride
Sex differences  neuronal development  dendritic spines  mrna translation  motor behavior  autism  ddx3x  nucleolus  ribosome biogenesis 
TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
TranscriptomicsDetection of chromothripsis-like patterns from custom array platform for chronic lymphocytic leukemia diagnosis (qchip Hemo custom array v3)
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western countries. The main genetic alterations associated to this disease are loss of 13q14, loss of 11q23, trisomy 12 and, less frequently, 17p13 losses, and are routinely studied using fluorescence in situ hybridization. These ge...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-66922 | biostudies-arrayexpress
TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
TranscriptomicsAnalysis of Spt16 depletion
Transcription rate analysis in Yeast by means of GRO, mRNA amount and ChIP-on-chip during the depletion of Spt16p. Keywords: Genomic run-on GRO ChIP-chip Transcription rate analysis by means of GRO and mRNA amount (RA) of three independent replicates during the depletion of Spt16p (Control and 5 &...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14082 | biostudies-arrayexpress
TranscriptomicsCCND2 rearrangements are the most frequent genetic events in Cyclin D1-negative mantle cell lymphoma [Agilent]
Cyclin D1-negative mantle cell lymphomas (MCL) are not well characterized, in part due to the difficulties in their recognition. SOX11 has been recently identified as a reliable biomarker of MCL, also expressed in the cyclin D1-negative variant. We investigated 40 lymphomas with MCL morphology and i...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42917 | biostudies-arrayexpress
TranscriptomicsCCND2 rearrangements are the most frequent genetic events in Cyclin D1-negative mantle cell lymphoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42854 | biostudies-arrayexpress
TranscriptomicsGene category-specific regulation of transcription elongation across the yeast genome
Analysis of genome-wide differences of transcription using Genomic run-on (GRO), RNApol II ChIP-on-Chip, cDNA analysis and ChIP-on-Chip. This SuperSeries is composed of the following subset Series: GSE14060 RNA pol II ChIP on chip (RPCC) GSE14077 RPCC analysis of rap1-sil, tpk1 & tpk2 GSE14080 ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14084 | biostudies-arrayexpress
TranscriptomicsCGH array of opportunistic strains
Genomic comparation of 3 opportunistic strains (60, 102 and D14) and one laboratory strain (W303) with the type strain S288C Comparison of each strain with the type strain. Biological replicates:2-3. One or two non-dye swap and one dye swap replicates were merged. One replicate per array
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-18 | E-GEOD-53440 | biostudies-arrayexpress
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