Sort   by:  
 Page size 
UnknownFunctional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in <i>Pseudomonas aeruginosa</i>.
A wide variety of clinically observed amino acid alterations in the Pseudomonas aeruginosa chromosomal β-lactamase AmpC (Pseudomonas-derived cephalosporinase [PDC]) are associated with increased resistance to cefepime, ceftolozane/tazobactam, or ceftazidime/avibactam, but their impact ...
S-EPMC12217463 | biostudies-literature
UnknownTargeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m<sup>6</sup>A protein synthesis routes.
Plitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect that plitidepsin decreases de novo cap-dependent translation of SARS-CoV-2 and non-viral RNAs but affects less than 13% of the host proteome, thus preserving cellula...
S-EPMC11805953 | biostudies-literature
UnknownN6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes methyltransferases and demethylases that add or remove this modification, as well as m6A-binding YTHDF proteins that promote...
S-EPMC5123813 | biostudies-literature
UnknownRv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress.
In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also nam...
S-EPMC6930017 | biostudies-literature
UnknownCOVIDiSTRESS diverse dataset on psychological and behavioural outcomes one year into the COVID-19 pandemic.
During the onset of the COVID-19 pandemic, the COVIDiSTRESS Consortium launched an open-access global survey to understand and improve individuals' experiences related to the crisis. A year later, we extended this line of research by launching a new survey to address the dynamic landscape of the pan...
S-EPMC9213519 | biostudies-literature
UnknownRole of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis.
Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the causative agent of human tuberculosis, has developed several strategies involving proteins and other compounds known collectively as virulence factors to subvert human host defences and invad...
S-EPMC3951760 | biostudies-literature
UnknownMETTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguano...
S-EPMC10386714 | biostudies-literature
GenomicsProteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)
Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
UnknownAntisense down-regulation of the strawberry β-galactosidase gene FaβGal4 increases cell wall galactose levels and reduces fruit softening.
Strawberry softening is characterized by an increase in the solubilization and depolymerization of pectins from cell walls. Galactose release from pectin side chains by β-galactosidase enzymes has been proposed as one reason for the increase in soluble pectins. A putative β-galactosidase gene, FaβGa...
S-EPMC4737064 | biostudies-literature
UnknownMonitoring the Phenolic Ripening of Red Grapes Using a Multisensor System Based on Metal-Oxide Nanoparticles.
The maturity of grapes is usually monitored by means of the sugar concentration. However, the assessment of other parameters such as the phenolic content is also important because the phenolic maturity has an important impact on the organoleptic characteristics of wines. In this work, voltammetric s...
S-EPMC5928143 | biostudies-literature
Sort   by:  
 Page size