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GenomicsEpigenomic profiling of Non-small-cell Lung Cancer (NSCLC) cells with or without Eed
Polycomb repressive complexes (PRC) are frequently implicated in human cancer acting either as oncogenes or tumor suppressors. Here we show that PRC2 is a critical regulator of Kras-driven non-small-cell lung cancer (NSCLC) progression. Modulation of PRC2 by either Ezh2 overexpression or Eed deletio...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-61190 | biostudies-arrayexpress
GenomicsChromatin accessibility, p300 and histone acetylation define PML-RARalpha- and AML1-ETO-binding sites
Chromatin accessibility is a key determinant of cell-type-specific gene expression. Here, we have investigated the chromatin architecture of different acute myeloid leukemia (AML) cells and the changes in accessibility when NB4 (APL) cells undergo the process of differentiation. For nuclease-accessi...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-30254 | biostudies-arrayexpress
GenomicsHDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibroadipogenic progenitors in dystrophic muscles
Fibro-adipogenic progenitors (FAPs) are emerging cellular components of the skeletal muscle regenerative environment. The alternative functional phenotype of FAPs - either supportive of muscle regeneration or promoting fibro-adipogenic degeneration M-bM-^@M-^S is a key determinant in the pathogenesi...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-52062 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis by Next Generation Sequencing of LSK (Lin- Sca1+ cKit+) hematopoietic progenitors and splenic B cells (naive and in vitro LPS activated) transcriptomes from Wild Type and Usp3-/- mice
Purpose: the goal of this study is to investigate the consequences of USP3 deletion on gene expression in mouse LSK hematopoietic progenitors and in splenic B cells Methods: mRNA profiles of 8 weeks-old wild-type (WT) and ubiquitin specific protease 3 knockout (Usp3−/−) mice were generated by deep ...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-58495 | biostudies-arrayexpress
TranscriptomicsFunctional Identification of Critical Bmi1 target genes in Neural Progenitor and Malignant Glioma cells
In this study, we combined a genome-wide analysis of the Polycomb protein Bmi1 and an in vivo RNAi screening to identify critical targets whose repression in neural progenitor and Malignant Glioma cells enables normal and aberrant self-renewal. Bmi1 ChIP-sequencing generated in 2 primary adult mouse...
ORGANISM(S): Mus musculus 
2013-05-21 | E-GEOD-33912 | biostudies-arrayexpress
UnknownSystematic Review of Renal Outcomes and Procedural Efficacy of Carbon Dioxide Digital Subtraction Angiography in Endovascular Aortic Repair
Not available
S-EPMC12936690 | biostudies-literature
UnknownSurfactant-derived proteins as markers of alveolar membrane damage in heart failure.
Not available
S-EPMC4267772 | biostudies-literature
UnknownThe Topology of a Discussion: The #Occupy Case.
Not available
S-EPMC4564107 | biostudies-literature
ProteomicsUSP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
To decipher the role of USP15 in DNA damage in leukemia cells, endogenous USP15 was immunoprecipitated from MV4-11 and Kasumi-1 cell lines under naive and DNA stress conditions (Mitomycin C, 30nM, 1h). 355 candidates co-immunoprecipitated with USP15 in all the conditions, in 4 independent experiment...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD020612 | Pride
Human Dna damage Ubiquitin 
UnknownThe spread of Carpophilus truncatus is on the razor's edge between an outbreak and a pest invasion.
Not available
S-EPMC9640586 | biostudies-literature
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