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GenomicsEpigenomic profiling of Non-small-cell Lung Cancer (NSCLC) cells with or without Eed
Polycomb repressive complexes (PRC) are frequently implicated in human cancer acting either as oncogenes or tumor suppressors. Here we show that PRC2 is a critical regulator of Kras-driven non-small-cell lung cancer (NSCLC) progression. Modulation of PRC2 by either Ezh2 overexpression or Eed deletio...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-61190 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis by Next Generation Sequencing of LSK (Lin- Sca1+ cKit+) hematopoietic progenitors and splenic B cells (naive and in vitro LPS activated) transcriptomes from Wild Type and Usp3-/- mice
Purpose: the goal of this study is to investigate the consequences of USP3 deletion on gene expression in mouse LSK hematopoietic progenitors and in splenic B cells Methods: mRNA profiles of 8 weeks-old wild-type (WT) and ubiquitin specific protease 3 knockout (Usp3−/−) mice were generated by deep ...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-58495 | biostudies-arrayexpress
UnknownmiR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis.
Not available
S-EPMC4423186 | biostudies-literature
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
GenomicsGene expression profiling of Eed knockout and Ezh2 knockout small intestinal crypts [ChIP-seq]
Polycomb-mediated gene repression plays an important role in adult stem cell maintenance. Direct targets of the Polycomb repressive complex PRC2 in th intestinal epithelium were revealed by performing ChIP-sequencing on crypt samples isolated from wild type murine small intestines. The resulting lis...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81577 | biostudies-arrayexpress
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