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TranscriptomicsRibo-seq of HEK293T overexpressing WT and G240R GARS
Charcot-Marie-Tooth (CMT) disease can be caused by mutations in Aminoacyl-tRNA-Synthetases, including G240R mutation in Glycyl-tRNA-Synthetase (GARS). Ribo-seq generates snapshots of translating ribosomes on mRNA and therefore allows analysis of ribosome pausing mRNA. Here we performed Ribo-seq on l...
ORGANISM(S): Homo sapiens 
2021-09-14 | E-MTAB-10342 | biostudies-arrayexpress
ProteomicsBinding of Glycyl-tRNA synthetase to the 3´UTR stimulates Mengovirus RNA translation
Picornaviruses are small viruses with a plus strand (i.e. mRNA orientation) RNA genome. Due to their limited coding capacity, these viruses use RNA secondary structures in their genomic RNAs like aptamers to bind cellular proteins. The resulting molecular interactions are then used to support transl...
ORGANISM(S): Viruses Homo sapiens (Human) Mengo virus 
2025-12-03 | PXD057754 | Pride
Picornavirus Aminoacyl-trna-synthetase Glyrs Mengovirus Gbe Poliovirus Mv Translation Gars binding element 
GenomicsSMAD1/5 binding regions of human umbilical vein endothelial cells (HUVECs) treated with BMP.
Smad1/5 binding regions were identified by ChIP-seq. HUVECs were treated with BMP for 1.5 h and anti-SMAD1/5 ChIP-seq analyses were performed using Illumina genome analyzer.
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-27634 | biostudies-arrayexpress
UnknownBinding of Glycyl-tRNA synthetase to Mengovirus RNA stimulates translation.
Not available
S-EPMC12781879 | biostudies-literature
TranscriptomicsExpression data of human umbilical vein endothelial cells (HUVECs) treated with BMP-6 and BMP-9
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. HUVECs were treated with BMP fo...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-27631 | biostudies-arrayexpress
GenomicsA mesodermal factor, T (Brachyury), specifies mouse germ cell fate by directly activating germline determinants
Germ cells ensure reproduction and heredity in metazoans. Primordial germ cells (PGCs) in mice are induced in pluripotent epiblasts by BMP4 and WNT3, yet their mechanism of action remains unclear. Here, using in vitro PGC specification system, we show that WNT3 induces many transcription factors a...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50394 | biostudies-arrayexpress
TranscriptomicsA Mesodermal Factor, T (BRACHYURY), specifies mouse germ cell fate by directly activating germline determinants.
The germ cell lineage ensures reproduction and heredity in metazoans. Primordial germ cells (PGCs) in mice are induced in pluripotent epiblast cells by BMP4 and WNT3, yet their mechanism of action remains elusive. Here, using in vitro PGC specification system, we show that WNT3, but not BMP4, induce...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-49689 | biostudies-arrayexpress
TranscriptomicsRNAseq of subepithelial connective tissue grafts obtained at different location and depth in the human palate
Aim: Identify set of genes, whose expression is dependent on the graft location in the patient’s palate (anterior vs. posterior) and depth of harvest (superficial vs. deep). The mRNA-Seq contains 64 human samples. The samples represent connective tissue grafts (CTGs) harvested at different locations...
ORGANISM(S): Homo sapiens 
2023-12-13 | E-MTAB-13141 | biostudies-arrayexpress
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