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UnknownConformational sampling of CMT-2D associated GlyRS mutations.
Not available
S-EPMC9731397 | biostudies-literature
UnknownAberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.
Not available
S-EPMC5843656 | biostudies-literature
UnknownAltered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels.
Not available
S-EPMC7431706 | biostudies-literature
ProteomicsDiverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecu...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038754 |
OthertRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase
Heterozygous mutations in six tRNA synthetase genes cause Charcot-Marie-Tooth (CMT) peripheral neuropathy. CMT-mutant glycyl- or tyrosyl-tRNA synthetases inhibit global protein synthesis by an unknown mechanism, independent of aminoacylation activity. We report that tRNAGly overexpression rescues pr...
ORGANISM(S): Mus musculus 
2021-09-07 | GSE160584 | GEO
UnknownGlycyl-tRNA sequestration is a unifying mechanism underlying GARS1-associated peripheral neuropathy.
Not available
S-EPMC11928938 | biostudies-literature
UnknownNeddylation requires glycyl-tRNA synthetase to protect activated E2.
Not available
S-EPMC4972647 | biostudies-literature
ProteomicsBinding of Glycyl-tRNA synthetase to the 3´UTR stimulates Mengovirus RNA translation
Picornaviruses are small viruses with a plus strand (i.e. mRNA orientation) RNA genome. Due to their limited coding capacity, these viruses use RNA secondary structures in their genomic RNAs like aptamers to bind cellular proteins. The resulting molecular interactions are then used to support transl...
ORGANISM(S): Viruses Homo sapiens (Human) Mengo virus 
2025-12-03 | PXD057754 | Pride
Picornavirus Aminoacyl-trna-synthetase Glyrs Mengovirus Gbe Poliovirus Mv Translation Gars binding element 
UnknownThe startle disease mutation α1S270T predicts shortening of glycinergic synaptic currents.
Not available
S-EPMC7649747 | biostudies-literature
UnknownZinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.
Not available
S-EPMC4452379 | biostudies-literature
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